Protein: ERCC8
DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA)

Gene: ERCC8
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q13216

Gene Ontology (top 5):
GO:0000012 - single strand break repair
GO:0000109 - nucleotide-excision repair complex
GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1042854

ERCC6
DNA excision repair protein ERCC-6

13

20

Small-scale

0.981

High

1098350

DDB1
DNA damage-binding protein 1

12

20

Small-scale

0.975

High

1098351

UVSSA
UV-stimulated scaffold protein A

6

0

Small-scale

0.885

High

1098372

DDA1
DET1- and DDB1-associated protein 1

3

4

Small-scale

0.827

High

1098341

ERCC8
DNA excision repair protein ERCC-8

2

17

Small-scale

0.768

High

1006998

TCPB
T-complex protein 1 subunit beta

3

20

Small-scale

0.757

High

1098343

CUL4A
Cullin-4A

13

20

Small-scale

0.757

High

1098344

CUL4B
Cullin-4B

8

20

Small-scale

0.751

High

1098357

CSN6
COP9 signalosome complex subunit 6

7

2

Small-scale

0.742

High

610641

TCPA
T-complex protein 1 subunit alpha

3

20

Small-scale

0.739

High

881901

TCPG
T-complex protein 1 subunit gamma

3

20

Small-scale

0.739

High

1098363

CSN5
COP9 signalosome complex subunit 5

6

7

Small-scale

0.729

High

1098386

CSN3
COP9 signalosome complex subunit 3

6

7

Small-scale

0.728

High

228709

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

19

High-throughput

0.691

High

1094322

CSN1
COP9 signalosome complex subunit 1

4

8

Small-scale

0.683

High

667289

RPB1
DNA-directed RNA polymerase II subunit RPB1

4

5

Small-scale

0.680

High

1098371

CSN4
COP9 signalosome complex subunit 4

4

3

Small-scale

0.676

High

1098383

CSN7A
COP9 signalosome complex subunit 7a

4

3

Small-scale

0.676

High

821330

TCPZ
T-complex protein 1 subunit zeta

2

20

Small-scale

0.675

High

875939

TCPE
T-complex protein 1 subunit epsilon

2

20

Small-scale

0.675

High

899019

TCPQ
T-complex protein 1 subunit theta

2

20

Small-scale

0.675

High

958629

CSN2
COP9 signalosome complex subunit 2

4

9

Small-scale

0.672

High

1098378

PFD4
Prefoldin subunit 4

3

5

Small-scale

0.667

High

1098373

SKI8
Superkiller complex protein 8

1

18

High-throughput

0.665

High

983782

RBX1
E3 ubiquitin-protein ligase RBX1

3

5

Small-scale

0.646

High

1098375

CSN7B
COP9 signalosome complex subunit 7b

3

3

Small-scale

0.640

High

162558

ANM5
Protein arginine N-methyltransferase 5

1

6

Small-scale

0.618

High

289520

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

20

Small-scale

0.618

High

532559

CH60
60 kDa heat shock protein, mitochondrial

1

14

Small-scale

0.618

High

899369

TCPD
T-complex protein 1 subunit delta

1

20

Small-scale

0.618

High

957351

UBC12
NEDD8-conjugating enzyme Ubc12

1

8

High-throughput

0.618

High

969831

RS16
Small ribosomal subunit protein uS9

1

9

High-throughput

0.618

High

992725

RACK1
Small ribosomal subunit protein RACK1

1

19

High-throughput

0.618

High

1062436

DHX9
ATP-dependent RNA helicase A

1

13

Small-scale

0.618

High

1098349

SF3B3
Splicing factor 3B subunit 3

1

20

Small-scale

0.618

High

1098352

DCAF6
DDB1- and CUL4-associated factor 6

1

18

High-throughput

0.618

High

1098354

PRP8
Pre-mRNA-processing-splicing factor 8

1

5

Small-scale

0.618

High

1098358

COP1
E3 ubiquitin-protein ligase COP1

1

17

High-throughput

0.618

High

1098362

DDB2
DNA damage-binding protein 2

1

17

Small-scale

0.618

High

1098368

CSN8
COP9 signalosome complex subunit 8

3

0

Small-scale

0.613

High

245928

KIF1B
Kinesin-like protein KIF1B

1

8

High-throughput

0.594

High

637491

FLNA
Filamin-A

2

15

Small-scale

0.584

High

1098367

PFD5
Prefoldin subunit 5

2

7

Small-scale

0.584

High

1098385

PFD2
Prefoldin subunit 2

2

4

Small-scale

0.584

High

1098345

TF2H2
General transcription factor IIH subunit 2

1

1

Small-scale

0.578

High

1098377

SYF1
Pre-mRNA-splicing factor SYF1

1

20

Small-scale

0.578

High

1098353

STXB5
Syntaxin-binding protein 5

1

14

High-throughput

0.553

High

1098369

TCPH
T-complex protein 1 subunit eta

1

20

Small-scale

0.553

High

1098364

CUL5
Cullin-5

1

20

High-throughput

0.536

High

1098380

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

1

High-throughput

0.536

High

182121

PFD6
Prefoldin subunit 6

2

7

Small-scale

0.533

High

176766

NACAD
NAC-alpha domain-containing protein 1

1

20

High-throughput

0.515

High

297596

PIAS1
E3 SUMO-protein ligase PIAS1

1

1

High-throughput

0.515

High

927275

ATX1
Ataxin-1

1

6

High-throughput

0.515

High

1098360

CSN9
COP9 signalosome complex subunit 9

1

0

High-throughput

0.513

High

995013

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.508

High

216680

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.493

High

1098365

RN183
E3 ubiquitin-protein ligase RNF183

1

0

High-throughput

0.493

High

1098374

FBX44
F-box only protein 44

1

2

High-throughput

0.489

High

1098342

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

3

High-throughput

0.481

High

124772

AIP
AH receptor-interacting protein

1

12

High-throughput

0.479

High

135603

DNM1L
Dynamin-1-like protein

1

7

Small-scale

0.479

High

144261

ACACB
Acetyl-CoA carboxylase 2

1

19

High-throughput

0.479

High

320669

UBXN7
UBX domain-containing protein 7

1

2

Small-scale

0.479

High

408043

TBB4A
Tubulin beta-4A chain

1

18

Small-scale

0.479

High

413753

P53
Cellular tumor antigen p53

1

9

Small-scale

0.479

High

424189

S10A8
Protein S100-A8

1

4

Small-scale

0.479

High

444969

S10A9
Protein S100-A9

1

4

Small-scale

0.479

High

455761

H10
Histone H1.0

1

2

Small-scale

0.479

High

476669

RSSA
Small ribosomal subunit protein uS2

1

2

Small-scale

0.479

High

537090

HSP7C
Heat shock cognate 71 kDa protein

1

13

Small-scale

0.479

High

542492

TOP2A
DNA topoisomerase 2-alpha

1

8

High-throughput

0.479

High

551022

PCNA
Proliferating cell nuclear antigen

1

1

Small-scale

0.479

High

587645

DESP
Desmoplakin

1

20

High-throughput

0.479

High

600293

ZNF24
Zinc finger protein 24

1

3

Small-scale

0.479

High

603260

KPCA
Protein kinase C alpha type

1

8

Small-scale

0.479

High

617160

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

17

Small-scale

0.479

High

620338

NUCL
Nucleolin

1

5

Small-scale

0.479

High

701144

PSB5
Proteasome subunit beta type-5

1

6

Small-scale

0.479

High

702942

DPOD1
DNA polymerase delta catalytic subunit

1

4

High-throughput

0.479

High

727783

DNJA1
DnaJ homolog subfamily A member 1

1

12

Small-scale

0.479

High

860728

RS10
Small ribosomal subunit protein eS10

1

6

Small-scale

0.479

High

862828

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

5

Small-scale

0.479

High

930875

HSP72
Heat shock-related 70 kDa protein 2

1

12

Small-scale

0.479

High

934555

TERA
Transitional endoplasmic reticulum ATPase

1

8

Small-scale

0.479

High

943234

RBM11
Splicing regulator RBM11

1

8

High-throughput

0.479

High

963286

PFD3
Prefoldin subunit 3

1

6

High-throughput

0.479

High

982419

RS15
Small ribosomal subunit protein uS19

1

1

Small-scale

0.479

High

983275

RS28
Small ribosomal subunit protein eS28

1

1

Small-scale

0.479

High

997311

TBB4B
Tubulin beta-4B chain

1

18

Small-scale

0.479

High

1028177

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.479

High

1030446

FABP5
Fatty acid-binding protein 5

1

1

High-throughput

0.479

High

1033667

PO5F1
POU domain, class 5, transcription factor 1

1

6

High-throughput

0.479

High

1036717

DSG1
Desmoglein-1

1

7

High-throughput

0.479

High

1048492

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

Small-scale

0.479

High

1067262

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

1098346

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

19

Small-scale

0.479

High

1098347

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

17

Small-scale

0.479

High

1098348

MVP
Major vault protein

1

1

Small-scale

0.479

High

1098355

BCOR
BCL-6 corepressor

1

13

High-throughput

0.479

High

1098359

HDAC7
Histone deacetylase 7

1

20

Small-scale

0.479

High

1098366

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

2

Small-scale

0.479

High

1098370

PCGF1
Polycomb group RING finger protein 1

1

19

High-throughput

0.479

High

1098376

NANOG
Homeobox protein NANOG

1

12

High-throughput

0.479

High

1098384

DNJB4
DnaJ homolog subfamily B member 4

1

11

Small-scale

0.479

High

1098387

RUVB2
RuvB-like 2

1

7

Small-scale

0.479

High

1098388

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

1

Small-scale

0.479

High

1098389

NUDC
Nuclear migration protein nudC

1

17

High-throughput

0.479

High

47327

A0A6Q8PF08
Peripheral myelin protein 22

1

1

High-throughput

0.470

High

570412

GFAP
Glial fibrillary acidic protein

1

8

High-throughput

0.470

High

954463

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

1

High-throughput

0.470

High

193369

OGG1
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

1

0

Small-scale

0.458

High

424402

HMGN1
Non-histone chromosomal protein HMG-14

1

0

Small-scale

0.458

High

1098356

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.458

High

1098379

F217B
Protein FAM217B

1

0

Small-scale

0.458

High

1098382

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

Small-scale

0.458

High

258858

DNJA2
DnaJ homolog subfamily A member 2

1

12

Small-scale

0.437

High

261798

PFD1
Prefoldin subunit 1

1

4

Small-scale

0.437

High

346997

BAG2
BAG family molecular chaperone regulator 2

1

2

Small-scale

0.437

High

653290

HEMH
Ferrochelatase, mitochondrial

1

1

Small-scale

0.437

High

592835

CBR1
Carbonyl reductase [NADPH] 1

1

2

High-throughput

0.417

High

541993

TOP1
DNA topoisomerase 1

1

4

Small-scale

0.408

High

1098361

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

1098381

IFNK
Interferon kappa

1

0

Small-scale

0.249

Low

168983

QCR8
Cytochrome b-c1 complex subunit 8

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025