HitPredict

Interactor 1: SLA2 (P33338)
Protein SLA2 (Transmembrane protein MOP2)
Gene: SLA2

Interactor 2: END3 (P39013)
Actin cytoskeleton-regulatory complex protein END3 (Endocytosis protein 3)
Gene: END3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.661

Property	Details
Experiments	18467557, 32400111, 37968396
Identification Methods	protein complementation assay, fluorescent resonance energy transfer, affinity chromatography technology, dihydrofolate reductase reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006897 - endocytosis GO:0007015 - actin filament organization GO:0030479 - actin cortical patch GO:0043332 - mating projection tip
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 968 Sc			1 349
+	Sc
		751841 SLA2_YEAST (1-968): 1.05e-71: 258: 100.00		EDE1_YEAST (3-262): 1.96e-26: 112: 16.73
+	Hs
		252752 AP180_HUMAN (6-276): 2.01e-56: 212: 15.71		EPS15_HUMAN (10-348): 3.04e-35: 138: 15.96
+	Hs
		839755 PICAL_HUMAN (6-331): 2.77e-54: 202: 13.99		EPS15_HUMAN (10-348): 3.04e-35: 138: 15.96
+	Sc
		739058 SLA2_YEAST (1-968): 1.05e-71: 258: 100.00		PAN1_YEAST (4-82): 1.09e-14: 77.3: 27.50
+	Hs
		130962 HIP1_HUMAN (4-965): 2.27e-61: 228: 18.85		ITSN1_HUMAN (124-245): 1.94e-09: 61.1: 10.66
+	Rn
		237000 PICAL_RAT (6-331): 2.29e-54: 202: 13.99		EHD2_RAT (77-223): 1.22e-13: 73.8: 17.69
+	Hs
		1107544 PICAL_HUMAN (6-331): 2.77e-54: 202: 13.99		ITSN1_HUMAN (124-245): 1.94e-09: 61.1: 10.66