Protein: AP180
Clathrin coat assembly protein AP180 (91 kDa synaptosomal-associated protein) (Clathrin coat-associated protein AP180) (Phosphoprotein F1-20)

Gene: AP180, SNAP91
Organism: Homo sapiens
Interactions: 61
UniProt ID: O60641

Gene Ontology (top 5):
GO:0000149 - SNARE binding
GO:0005545 - 1-phosphatidylinositol binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005905 - clathrin-coated pit
GO:0006900 - vesicle budding from membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

252761

PICAL
Phosphatidylinositol-binding clathrin assembly protein

2

7

High-throughput

0.776

High

124164

HAX1
HCLS1-associated protein X-1

3

1

High-throughput

0.667

High

252752

EPS15
Epidermal growth factor receptor substrate 15

2

11

Small-scale

0.619

High

252743

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

5

High-throughput

0.618

High

252744

TAU
Microtubule-associated protein tau

2

14

High-throughput

0.611

High

252767

DGUOK
Deoxyguanosine kinase, mitochondrial

3

1

High-throughput

0.609

High

252756

GEM
GTP-binding protein GEM

2

1

High-throughput

0.553

High

252777

MIPO1
Mirror-image polydactyly gene 1 protein

2

2

High-throughput

0.553

High

252792

ABI2
Abl interactor 2

2

9

High-throughput

0.553

High

252751

BRCA1
Breast cancer type 1 susceptibility protein

2

6

High-throughput

0.549

High

252764

PCM1
Pericentriolar material 1 protein

2

1

High-throughput

0.549

High

252782

TRI44
Tripartite motif-containing protein 44

2

1

High-throughput

0.549

High

252786

MELPH
Melanophilin

2

2

High-throughput

0.549

High

252778

MIPT3
TRAF3-interacting protein 1

2

5

High-throughput

0.539

High

252755

CLH2
Clathrin heavy chain 2

1

9

High-throughput

0.536

High

252765

RABE1
Rab GTPase-binding effector protein 1

1

6

High-throughput

0.536

High

252779

RBCC1
RB1-inducible coiled-coil protein 1

1

11

High-throughput

0.536

High

252740

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

15

High-throughput

0.526

High

252749

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

17

High-throughput

0.526

High

252766

ERBB4
Receptor tyrosine-protein kinase erbB-4

2

16

High-throughput

0.526

High

252768

GLE1
mRNA export factor GLE1

1

6

High-throughput

0.515

High

252772

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

2

High-throughput

0.515

High

252795

RABX5
Rab5 GDP/GTP exchange factor

1

0

High-throughput

0.513

High

252748

VINC
Vinculin

1

2

High-throughput

0.489

High

252753

PEX5
Peroxisomal targeting signal 1 receptor

1

6

High-throughput

0.489

High

252754

GPM6A
Neuronal membrane glycoprotein M6-a

1

2

High-throughput

0.489

High

252759

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

16

High-throughput

0.489

High

252762

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.489

High

252763

SETB1
Histone-lysine N-methyltransferase SETDB1

1

3

High-throughput

0.489

High

252774

MIB1
E3 ubiquitin-protein ligase MIB1

1

4

High-throughput

0.489

High

252776

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

5

High-throughput

0.489

High

252785

DCAF5
DDB1- and CUL4-associated factor 5

1

7

High-throughput

0.489

High

252790

SENP3
Sentrin-specific protease 3

1

1

High-throughput

0.489

High

252793

MS18A
Protein Mis18-alpha

1

1

High-throughput

0.489

High

252758

CLH1
Clathrin heavy chain 1

1

9

Small-scale

0.479

High

252760

AP1B1
AP-1 complex subunit beta-1

1

15

Small-scale

0.479

High

252781

TITIN
Titin

1

5

High-throughput

0.479

High

252739

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

252789

DNJC5
DnaJ homolog subfamily C member 5

1

4

High-throughput

0.457

High

135853

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

1

High-throughput

0.445

High

104921

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

252745

FGFR1
Fibroblast growth factor receptor 1

1

10

High-throughput

0.437

High

252746

LYL1
Protein lyl-1

1

3

High-throughput

0.437

High

252757

ARF6
ADP-ribosylation factor 6

1

1

Small-scale

0.437

High

252771

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.437

High

252775

SMC5
Structural maintenance of chromosomes protein 5

1

4

High-throughput

0.437

High

252741

JUN
Transcription factor Jun

1

6

High-throughput

0.407

High

252770

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

3

High-throughput

0.407

High

252773

DSG4
Desmoglein-4

1

4

High-throughput

0.407

High

252780

LRC15
Leucine-rich repeat-containing protein 15

1

1

High-throughput

0.407

High

252783

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

1

1

High-throughput

0.407

High

252784

STALP
AMSH-like protease

1

1

High-throughput

0.407

High

252791

KTU
Protein kintoun

3

0

High-throughput

0.347

High

252794

NUFP1
FMR1-interacting protein NUFIP1

3

0

High-throughput

0.347

High

252769

BOREA
Borealin

2

0

High-throughput

0.318

High

252738

GEMI
Geminin

1

0

High-throughput

0.279

Low

252742

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

0

High-throughput

0.279

Low

252787

NTM1A
N-terminal Xaa-Pro-Lys N-methyltransferase 1

1

0

High-throughput

0.279

Low

252788

FANCJ
Fanconi anemia group J protein

1

0

High-throughput

0.279

Low

252747

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.249

Low

252750

SPB5
Serpin B5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025