HitPredict

Interactor 1: CIC1 (P38779)
Proteasome-interacting protein CIC1 (Core interacting component 1)
Gene: CIC1

Interactor 2: HAS1 (Q03532)
ATP-dependent RNA helicase HAS1 (EC 3.6.4.13) (Helicase associated with SET1 protein 1)
Gene: HAS1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.964

Property	Details
Experiments	30568249, 31511893, 12374754, 16554755, 16429126, 35385737, 37968396, 24129494
Identification Methods	affinity chromatography technology, two hybrid, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Helicase_C~Ribosomal_L1
Common GO terms	GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0003723 - RNA binding GO:0005730 - nucleolus GO:0030686 - 90S preribosome GO:0030687 - preribosome, large subunit precursor
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 376 Sc			1 505
+	Sc
		624078 CIC1_YEAST (1-376): 1.89e-149: 428: 100.00		DBP2_YEAST (5-421): 8.67e-134: 400: 29.22
+	Sc
		699678 CIC1_YEAST (1-376): 1.89e-149: 428: 100.00		DRS1_YEAST (26-394): 3.8e-72: 245: 38.32
+	Sc
		593624 RL1D1_YEAST (75-292): 1.46e-51: 175: 22.79		DBP4_YEAST (3-501): 9.9e-165: 486: 37.70
+	Sc
		548402 CIC1_YEAST (1-376): 1.89e-149: 428: 100.00		MS116_YEAST (5-409): 4.69e-64: 221: 35.63
+	Sc
		638743 CIC1_YEAST (1-376): 1.89e-149: 428: 100.00		SPB4_YEAST (56-488): 1.9e-61: 213: 33.41
+	Hs
		281443 RL1D1_HUMAN (55-294): 6.21e-55: 189: 20.91		DDX18_HUMAN (2-492): 3.3e-139: 418: 59.76
+	Hs
		281420 RL1D1_HUMAN (55-294): 6.21e-55: 189: 20.91		DDX31_HUMAN (9-505): 3.72e-82: 274: 32.37