Interactor 1: MCM4 (P33991)
DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)
Gene: MCM4
Interactor 2: MCM6 (Q14566)
DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)
Gene: MCM6
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.95 | 1.00 | 0.976 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26496610, 27173435, 17296731, 12614612, 12207017, 31839598, 12694531, 8798650, 35235311, 37071682, 39358380, 12364596 |
| Identification Methods | affinity chromatography technology, two hybrid, cross-linking study, pull down, anti tag coimmunoprecipitation, tandem affinity purification, coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | MCM~MCM, MCM~MCM6_C, MCM~MCM_lid, MCM~MCM_N, MCM~MCM_OB, MCM~MCM4_WHD, MCM4_WHD~MCM_lid, MCM6_C~MCM_lid, MCM_N~MCM_N, MCM_N~MCM_OB, MCM_OB~MCM_OB |
| Common GO terms | GO:0000727 - double-strand break repair via break-induced replication GO:0000781 - chromosome, telomeric region GO:0003678 - DNA helicase activity GO:0003697 - single-stranded DNA binding GO:0005524 - ATP binding and 7 others more... |
| Homologous interactions | 19 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
