HitPredict

Interactor 1: GARE2 (Q75VX8)
GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like)
Gene: GAREM2

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.439

Property	Details
Experiments	22558309
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 874 Hs			1 1697
+	Hs
		1332845 GARE1_HUMAN (4-874): 0: 651: 40.92		ITSN2_HUMAN (1-1697): 0: 969: 100.00
+	Hs
		1078850 GARE2_HUMAN (1-874): 0: 605: 100.00		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		610517 CBL_HUMAN (491-829): 7.04e-22: 103: 16.52		ITSN2_HUMAN (1-1697): 0: 969: 100.00
+	Hs
		1349277 DAPLE_HUMAN (336-850): 2.01e-09: 63.8: 12.93		ITSN2_HUMAN (1-1697): 0: 969: 100.00
+	Mm
		610657 CBL_MOUSE (446-859): 3.64e-23: 108: 15.24		ITSN2_MOUSE (1-1697): 0: 904: 88.92
+	Mm
		610656 CBL_MOUSE (446-859): 3.64e-23: 108: 15.24		ITSN1_MOUSE (2-1693): 0: 861: 56.37
+	Hs
		610415 CBL_HUMAN (491-829): 7.04e-22: 103: 16.52		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		203228 SYNJ1_HUMAN (280-662): 6.77e-09: 61.9: 14.89		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		1332846 GARE1_HUMAN (4-874): 0: 651: 40.92		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Ce
		136804 UNC89_CAEEL (295-573): 5.72e-10: 65.8: 10.88		VAV_CAEEL (1141-1621): 1.34e-70: 260: 16.44
+	Hs
		610520 CBL_HUMAN (491-829): 7.04e-22: 103: 16.52		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Rn
		1126747 SYNJ1_RAT (316-729): 2.9e-14: 79.6: 11.54		Q5JC29_RAT (7-410): 1.28e-31: 136: 18.55
+	Hs
		610518 CBL_HUMAN (491-829): 7.04e-22: 103: 16.52		ARHGC_HUMAN (1189-1535): 2.93e-21: 103: 27.07
+	Mm
		610601 CBL_MOUSE (446-859): 3.64e-23: 108: 15.24		EP15R_MOUSE (13-132): 1.69e-16: 87.7: 27.87
+	Hs
		548639 CBL_HUMAN (491-829): 7.04e-22: 103: 16.52		VAV_HUMAN (526-1189): 1.23e-13: 78.3: 13.15
+	Hs
		610397 CBL_HUMAN (491-829): 7.04e-22: 103: 16.52		ARHG7_HUMAN (770-1003): 4.21e-12: 73.3: 18.14
+	Hs
		610308 CBL_HUMAN (491-829): 7.04e-22: 103: 16.52		VAV2_HUMAN (614-1182): 8.45e-12: 72.6: 12.07
+	Hs
		610407 CBL_HUMAN (491-829): 7.04e-22: 103: 16.52		ARHG6_HUMAN (878-973): 2.21e-11: 71: 23.71
+	Hs
		203230 SYNJ1_HUMAN (280-662): 6.77e-09: 61.9: 14.89		SH319_HUMAN (1035-1211): 6.54e-11: 69.3: 28.26