HitPredict

Interactor 1: MCM7 (P33993)
DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)
Gene: MCM7

Interactor 2: MCM6 (Q14566)
DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)
Gene: MCM6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.975

The method score is based on:

Property Details
Experiments 27173435, 17296731, 12614612, 9099751, 31839598, 26496610, 12694531, 12207017, 16438930, 33654309, 23764002
Identification Methods affinity chromatography technology, two hybrid, cross-linking study, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains MCM~MCM, MCM~MCM6_C, MCM~MCM_lid, MCM~MCM_N, MCM~MCM_OB, MCM6_C~MCM_lid, MCM_N~MCM_N, MCM_N~MCM_OB, MCM_OB~MCM_OB
Common GO terms GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0003678 - DNA helicase activity
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding
and 8 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 719
Hs

1 821
+ Xl
+ Dm
+ At
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Xl
+ Xl
+ Xl
+ Xl
+ Xl
+ Dm
+ Dm
+ Dm
+ Hs
+ Hs
+ Hs

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Last updated: 11Aug2025