HitPredict

Interactor 1: RSP5 (P39940)
E3 ubiquitin-protein ligase RSP5 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase RSP5) (Reverses SPT-phenotype protein 5)
Gene: RSP5

Interactor 2: UBC7 (Q02159)
Ubiquitin-conjugating enzyme E2 7 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 7) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-18 kDa) (Ubiquitin-protein ligase)
Gene: UBC7

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15643069
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0006325 - chromatin organization GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 809 Sc			1 165
+	Sc
		549815 RSP5_YEAST (1-809): 0: 825: 100.00		UBC4_YEAST (1-163): 5.02e-72: 215: 35.58
+	Sc
		549857 RSP5_YEAST (1-809): 0: 825: 100.00		UBC5_YEAST (1-163): 2.49e-71: 213: 34.36
+	Sc
		539472 RSP5_YEAST (1-809): 0: 825: 100.00		UBC3_YEAST (4-162): 1.54e-35: 126: 41.36
+	Hs
		1294888 ITCH_HUMAN (1-809): 0: 727: 34.62		UB2D4_HUMAN (4-164): 1.63e-73: 218: 36.65
+	Sp
		145419 PUB3_SCHPO (4-809): 0: 733: 54.05		UBC4_SCHPO (4-163): 3.38e-71: 212: 36.25
+	Hs
		849411 ITCH_HUMAN (1-809): 0: 727: 34.62		UB2D1_HUMAN (4-164): 7.38e-73: 217: 36.65
+	Hs
		919827 ITCH_HUMAN (1-809): 0: 727: 34.62		UB2D2_HUMAN (4-164): 1.2e-72: 216: 36.03
+	Hs
		895882 ITCH_HUMAN (1-809): 0: 727: 34.62		UB2D3_HUMAN (4-164): 2.23e-71: 213: 36.03
+	Hs
		908265 ITCH_HUMAN (1-809): 0: 727: 34.62		UB2G1_HUMAN (4-162): 7.38e-69: 207: 50.00
+	Hs
		1294835 ITCH_HUMAN (1-809): 0: 727: 34.62		UB2E2_HUMAN (3-163): 6.79e-68: 206: 34.16
+	Hs
		849452 SMUF1_HUMAN (4-809): 0: 701: 36.64		UB2D1_HUMAN (4-164): 7.38e-73: 217: 36.65
+	Hs
		919869 SMUF1_HUMAN (4-809): 0: 701: 36.64		UB2D2_HUMAN (4-164): 1.2e-72: 216: 36.03
+	Hs
		895919 SMUF1_HUMAN (4-809): 0: 701: 36.64		UB2D3_HUMAN (4-164): 2.23e-71: 213: 36.03
+	Hs
		908269 SMUF1_HUMAN (4-809): 0: 701: 36.64		UB2G1_HUMAN (4-162): 7.38e-69: 207: 50.00
+	Hs
		849444 WWP1_HUMAN (108-809): 0: 690: 40.33		UB2D1_HUMAN (4-164): 7.38e-73: 217: 36.65
+	Hs
		919860 WWP1_HUMAN (108-809): 0: 690: 40.33		UB2D2_HUMAN (4-164): 1.2e-72: 216: 36.03
+	Hs
		895910 WWP1_HUMAN (108-809): 0: 690: 40.33		UB2D3_HUMAN (4-164): 2.23e-71: 213: 36.03
+	Hs
		1174523 ITCH_HUMAN (1-809): 0: 727: 34.62		UB2R2_HUMAN (4-148): 2.6e-40: 137: 47.97
+	Hs
		828008 ITCH_HUMAN (1-809): 0: 727: 34.62		UB2R1_HUMAN (4-145): 1.59e-40: 137: 49.30
+	Hs
		125247 WWP2_HUMAN (100-809): 0: 684: 40.81		UB2R1_HUMAN (4-145): 1.59e-40: 137: 49.30