HitPredict

Interactor 1: RSP5 (P39940)
E3 ubiquitin-protein ligase RSP5 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase RSP5) (Reverses SPT-phenotype protein 5)
Gene: RSP5

Interactor 2: PIN3 (Q06449)
[PSI+] inducibility protein 3 (LAS seventeen-binding protein 2) (LAS17-binding protein 2)
Gene: PIN3

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	26508657, 22000681
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0030479 - actin cortical patch
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 809 Sc			1 215
+	Sc
		765339 RSP5_YEAST (1-809): 0: 825: 100.00		LSB1_YEAST (1-215): 8.56e-34: 122: 46.28
+	Hs
		1270607 ITCH_HUMAN (1-809): 0: 727: 34.62		STAM1_HUMAN (2-200): 2.11e-32: 124: 14.42
+	Hs
		277114 ITCH_HUMAN (1-809): 0: 727: 34.62		STAM2_HUMAN (4-200): 6.69e-32: 122: 14.83
+	Hs
		1049723 ITCH_HUMAN (1-809): 0: 727: 34.62		ARHG7_HUMAN (14-181): 7e-30: 118: 15.48
+	Hs
		1054789 ITCH_HUMAN (1-809): 0: 727: 34.62		CASL_HUMAN (59-195): 3.73e-29: 116: 22.92
+	Hs
		1294845 ITCH_HUMAN (1-809): 0: 727: 34.62		SH3G2_HUMAN (10-115): 9.95e-29: 111: 20.76
+	Hs
		1294844 ITCH_HUMAN (1-809): 0: 727: 34.62		SH3G1_HUMAN (16-113): 2.65e-27: 108: 28.28
+	Hs
		1294846 ITCH_HUMAN (1-809): 0: 727: 34.62		SH3G3_HUMAN (46-109): 4.28e-24: 99.5: 34.38
+	Hs
		275221 ITCH_HUMAN (1-809): 0: 727: 34.62		GRAP2_HUMAN (49-110): 1.79e-19: 86.4: 33.87
+	Hs
		125613 WWP2_HUMAN (100-809): 0: 684: 40.81		STAM1_HUMAN (2-200): 2.11e-32: 124: 14.42
+	Hs
		1078893 ITCH_HUMAN (1-809): 0: 727: 34.62		ITSN1_HUMAN (38-128): 8.43e-14: 71.5: 20.83
+	Hs
		1299605 NED4L_HUMAN (145-806): 0: 676: 43.87		STAC_HUMAN (18-130): 5.39e-27: 108: 30.70
+	Hs
		125051 WWP2_HUMAN (100-809): 0: 684: 40.81		GRAP2_HUMAN (49-110): 1.79e-19: 86.4: 33.87
+	Hs
		125348 WWP2_HUMAN (100-809): 0: 684: 40.81		GRB2_HUMAN (59-109): 8.42e-20: 85.3: 36.54
+	Hs
		1054795 SMUF2_HUMAN (230-809): 0: 640: 42.86		CASL_HUMAN (59-195): 3.73e-29: 116: 22.92
+	Sc
		975839 TOM1_YEAST (370-808): 5.87e-157: 509: 37.36		PIN3_YEAST (1-215): 1.32e-44: 149: 100.00