HitPredict

Interactor 1: NMDZ1 (P35438)
Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)
Gene: Grin1

Interactor 2: AGAP2 (Q3UHD9)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE)
Gene: AGAP2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28706196
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0030425 - dendrite GO:0043524 - negative regulation of neuron apoptotic process GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0098978 - glutamatergic synapse
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 938 Mm			1 1186
+	Rn
		623665 GRIA1_RAT (6-904): 0: 679: 21.15		AGAP2_RAT (1-1186): 0: 988: 99.07
+	Mm
		663026 GRIA1_MOUSE (6-904): 0: 676: 21.25		AGAP2_MOUSE (1-1186): 0: 988: 100.00
+	Mm
		1029191 NMDE2_MOUSE (4-938): 0: 641: 23.86		AGAP2_MOUSE (1-1186): 0: 988: 100.00
+	Mm
		104740 F6YNQ1_MOUSE (83-904): 0: 638: 21.97		AGAP2_MOUSE (1-1186): 0: 988: 100.00
+	Rn
		623688 GRIA2_RAT (4-856): 0: 637: 21.69		AGAP2_RAT (1-1186): 0: 988: 99.07
+	Mm
		663090 GRIA2_MOUSE (4-856): 0: 637: 21.69		AGAP2_MOUSE (1-1186): 0: 988: 100.00
+	Hs
		838504 GRIA2_HUMAN (4-856): 0: 640: 21.69		AGAP2_HUMAN (1-1186): 0: 975: 93.29
+	Mm
		771417 NMDE1_MOUSE (1-923): 0: 607: 24.22		AGAP2_MOUSE (1-1186): 0: 988: 100.00
+	Mm
		771448 NMDZ1_MOUSE (1-938): 0: 934: 100.00		RAP1A_MOUSE (398-563): 1.9e-69: 232: 23.84
+	Mm
		982147 NMDE2_MOUSE (4-938): 0: 641: 23.86		RAP1A_MOUSE (398-563): 1.9e-69: 232: 23.84