Interactor 1: VHL (P40337)
von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)
Gene: VHL
Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.99 | 1.00 | 0.999 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25361009, 25500545, 26611735, 26215701, 23413029, 26743088, 27281823, 12101228, 27563096, 28775317, 15833858, 18062927, 20458141, 21316481, 14556007, 17442832, 22369643, 30988076, 28425505, 32589900 and 106 others
more... |
| Identification Methods | affinity chromatography technology, pull down, enzymatic study, two hybrid, x-ray crystallography, unspecified method, far western blotting, protein complementation assay, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation and 3 others
more... |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | HIF-1~VHL |
| Common GO terms | GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006355 - regulation of DNA-templated transcription GO:0010468 - regulation of gene expression and 4 others more... |
| Homologous interactions | 8 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
