Protein: P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)

Gene: P5CR1, PYCR1
Organism: Homo sapiens
Interactions: 196
UniProt ID: P32322

Gene Ontology (top 5):
GO:0004735 - pyrroline-5-carboxylate reductase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006561 - proline biosynthetic process
GO:0034599 - cellular response to oxidative stress

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

687258

P5CR2
Pyrroline-5-carboxylate reductase 2

4

14

High-throughput

0.895

High

687224

P5CR3
Pyrroline-5-carboxylate reductase 3

3

14

High-throughput

0.861

High

687171

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

2

14

Small-scale

0.789

High

63297

MET15
12S rRNA N4-methylcytidine

2

1

High-throughput

0.611

High

440368

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

2

1

High-throughput

0.611

High

687177

GRP75
Stress-70 protein, mitochondrial

2

3

High-throughput

0.611

High

687183

IF2M
Translation initiation factor IF-2, mitochondrial

2

2

High-throughput

0.611

High

687234

KLD10
Kelch domain-containing protein 10

3

1

High-throughput

0.609

High

687310

NUDT5
ADP-sugar pyrophosphatase

3

1

High-throughput

0.609

High

226650

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

262728

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

377133

GCR
Glucocorticoid receptor

2

2

Small-scale

0.584

High

525435

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

1

High-throughput

0.584

High

687202

GRSF1
G-rich sequence factor 1

2

4

High-throughput

0.584

High

687221

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

687294

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

3

Small-scale

0.578

High

687213

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

2

7

Small-scale

0.571

High

304921

DUS14
Dual specificity protein phosphatase 14

2

1

High-throughput

0.558

High

687227

CE162
Centrosomal protein of 162 kDa

2

3

High-throughput

0.537

High

157427

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

1

High-throughput

0.536

High

687254

GTPB3
tRNA modification GTPase GTPBP3, mitochondrial

1

2

High-throughput

0.536

High

346056

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.533

High

687184

PAXI
Paxillin

2

1

High-throughput

0.521

High

687236

SYDE1
Rho GTPase-activating protein SYDE1

2

3

High-throughput

0.521

High

687241

LCA5
Lebercilin

2

1

High-throughput

0.521

High

687245

SH2D3
SH2 domain-containing protein 3C

2

2

High-throughput

0.521

High

687312

RHG26
Rho GTPase-activating protein 26

2

1

High-throughput

0.521

High

167207

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.513

High

670530

AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

687187

RT29
Small ribosomal subunit protein mS29

1

0

High-throughput

0.513

High

687272

MIPEP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.513

High

687251

CBP
CREB-binding protein

1

2

Small-scale

0.512

High

687270

PARK7
Parkinson disease protein 7

1

0

Small-scale

0.512

High

687186

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.494

High

131640

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

1

1

High-throughput

0.489

High

682704

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

4

High-throughput

0.489

High

687188

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

4

High-throughput

0.489

High

687204

CDC16
Cell division cycle protein 16 homolog

1

4

High-throughput

0.489

High

687207

CUL3
Cullin-3

1

2

High-throughput

0.489

High

687260

APC16
Anaphase-promoting complex subunit 16

1

1

High-throughput

0.489

High

687307

CDC23
Cell division cycle protein 23 homolog

1

4

High-throughput

0.489

High

687308

APC4
Anaphase-promoting complex subunit 4

1

1

High-throughput

0.489

High

687309

ANC2
Anaphase-promoting complex subunit 2

1

4

High-throughput

0.489

High

59122

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

203883

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.479

High

264852

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

269988

RF1M
Peptide chain release factor 1, mitochondrial

1

5

High-throughput

0.479

High

276791

SCO1
Protein SCO1 homolog, mitochondrial

1

1

High-throughput

0.479

High

325054

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.479

High

327369

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

336846

OTC
Ornithine transcarbamylase, mitochondrial

1

1

High-throughput

0.479

High

486470

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

499567

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

687175

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

687178

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

687179

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

687182

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

687194

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.479

High

687198

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

687199

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

687201

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

687203

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.479

High

687208

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

687211

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.479

High

687217

PDK1
[Pyruvate dehydrogenase

1

4

High-throughput

0.479

High

687218

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

687225

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

687230

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

687232

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

3

High-throughput

0.479

High

687237

DHX30
ATP-dependent RNA helicase DHX30

1

1

High-throughput

0.479

High

687238

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

7

High-throughput

0.479

High

687242

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.479

High

687246

MCU
Calcium uniporter protein, mitochondrial

1

3

High-throughput

0.479

High

687252

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.479

High

687253

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

5

High-throughput

0.479

High

687255

FAKD4
FAST kinase domain-containing protein 4

1

7

High-throughput

0.479

High

687256

MCUR1
Mitochondrial calcium uniporter regulator 1

1

3

High-throughput

0.479

High

687257

CHCH1
Small ribosomal subunit protein mS37

1

1

High-throughput

0.479

High

687259

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

3

High-throughput

0.479

High

687261

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

1

High-throughput

0.479

High

687262

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

687264

COX14
Cytochrome c oxidase assembly protein COX14

1

1

High-throughput

0.479

High

687265

IMP1L
Mitochondrial inner membrane protease subunit 1

1

3

High-throughput

0.479

High

687266

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.479

High

687267

EFGM
Elongation factor G, mitochondrial

1

5

High-throughput

0.479

High

687273

TACO1
Translational activator of cytochrome c oxidase 1

1

2

High-throughput

0.479

High

687275

TR61B
tRNA

1

1

High-throughput

0.479

High

687276

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

687277

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

687281

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

687282

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

3

High-throughput

0.479

High

687284

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

687285

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

687286

MTRFR
Mitochondrial translation release factor in rescue

1

5

High-throughput

0.479

High

687287

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

687288

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

687289

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

687290

SFXN1
Sideroflexin-1

1

1

High-throughput

0.479

High

687292

NGRN
Neugrin

1

1

High-throughput

0.479

High

687295

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.479

High

687296

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

687297

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

3

High-throughput

0.479

High

687299

RMND1
Required for meiotic nuclear division protein 1 homolog

1

1

High-throughput

0.479

High

687300

AKIP
Small ribosomal subunit protein mS38

1

1

High-throughput

0.479

High

687301

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

7

High-throughput

0.479

High

687303

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

687304

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

5

High-throughput

0.479

High

687313

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.479

High

687244

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

1

High-throughput

0.470

High

373776

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

687191

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

946

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.445

High

496420

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

687226

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

687317

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

3

High-throughput

0.445

High

165636

SET1A
Histone-lysine N-methyltransferase SETD1A

1

2

High-throughput

0.437

High

172982

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.437

High

294437

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.437

High

324252

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.437

High

384361

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

548058

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

3

Small-scale

0.437

High

609188

FGFR3
Fibroblast growth factor receptor 3

1

4

High-throughput

0.437

High

684434

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.437

High

687172

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.437

High

687174

FUS
RNA-binding protein FUS

1

1

High-throughput

0.437

High

687180

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

5

High-throughput

0.437

High

687181

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.437

High

687185

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

687190

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.437

High

687192

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.437

High

687196

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.437

High

687197

TLE2
Transducin-like enhancer protein 2

1

3

High-throughput

0.437

High

687200

QOR
Quinone oxidoreductase

1

1

High-throughput

0.437

High

687205

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.437

High

687206

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

687210

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.437

High

687212

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.437

High

687215

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.437

High

687219

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

687223

SMU1
WD40 repeat-containing protein SMU1

1

3

High-throughput

0.437

High

687228

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.437

High

687233

CH082
UPF0598 protein C8orf82

1

1

High-throughput

0.437

High

687235

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

687240

ZCH18
Zinc finger CCCH domain-containing protein 18

1

3

High-throughput

0.437

High

687247

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.437

High

687248

COP1
E3 ubiquitin-protein ligase COP1

1

6

High-throughput

0.437

High

687250

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.437

High

687268

IMP2L
Mitochondrial inner membrane protease subunit 2

1

3

High-throughput

0.437

High

687269

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.437

High

687274

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.437

High

687305

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

687311

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.437

High

687315

DJC15
DnaJ homolog subfamily C member 15

1

2

High-throughput

0.437

High

121447

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

1

High-throughput

0.407

High

154547

ZN213
Zinc finger protein 213

1

1

High-throughput

0.407

High

581479

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.407

High

687278

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

1

High-throughput

0.407

High

687283

5NT3A
Cytosolic 5'-nucleotidase 3A

1

1

High-throughput

0.407

High

155539

TNPO2
Transportin-2

2

0

High-throughput

0.316

High

498222

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

0

High-throughput

0.298

High

671606

PEBP1
Phosphatidylethanolamine-binding protein 1

2

0

High-throughput

0.298

High

60301

POTEF
POTE ankyrin domain family member F

1

0

High-throughput

0.279

Low

687173

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

687189

IF4A1
Eukaryotic initiation factor 4A-I

1

0

High-throughput

0.279

Low

687231

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

687263

ZHX1R
Zinc fingers and homeoboxes protein 1, isoform 2

1

0

High-throughput

0.279

Low

687306

GCP4
Gamma-tubulin complex component 4

1

0

High-throughput

0.279

Low

687316

NPTN
Neuroplastin

1

0

High-throughput

0.279

Low

214864

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.265

Low

279794

CDKA2
Cyclin-dependent kinase 2-associated protein 2

1

0

High-throughput

0.265

Low

687209

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

High-throughput

0.251

Low

687239

BNIPL
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein

1

0

High-throughput

0.251

Low

148443

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

390734

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

503538

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.249

Low

530460

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

687176

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.249

Low

687193

DAB2
Disabled homolog 2

1

0

Small-scale

0.249

Low

687195

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

687214

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.249

Low

687216

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

687220

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

687222

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

687229

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

687243

MILK2
MICAL-like protein 2

1

0

High-throughput

0.249

Low

687249

DEP1B
DEP domain-containing protein 1B

1

0

High-throughput

0.249

Low

687271

TBX5
T-box transcription factor TBX5

1

0

High-throughput

0.249

Low

687280

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.249

Low

687291

MYO10
Unconventional myosin-X

1

0

Small-scale

0.249

Low

687293

ANLN
Anillin

1

0

High-throughput

0.249

Low

687298

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

687302

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

687314

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

401497

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

687279

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024