HitPredict

Interactor 1: VHL (P40337)
von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)
Gene: VHL

Interactor 2: UBE2S (Q16763)
Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S)
Gene: UBE2S

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.708

Property	Details
Experiments	27685940, 30903204, 32328410, 32814053
Identification Methods	pull down, enzymatic study, affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 213 Hs			1 222
+	Hs
		771887 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		UB2D2_HUMAN (12-157): 1.45e-81: 241: 36.99
+	Hs
		771845 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		UB2D1_HUMAN (12-157): 5.26e-81: 240: 35.62
+	Hs
		771862 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		UB2D3_HUMAN (12-157): 3.99e-80: 237: 35.62
+	Hs
		771865 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		UBE2N_HUMAN (12-159): 5.26e-72: 217: 37.16