HitPredict

Interactor 1: ACTN2 (P35609)
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
Gene: ACTN2

Interactor 2: SCRIB (Q14160)
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Gene: SCRIB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24550280
Identification Methods	phage display
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030054 - cell junction GO:0070062 - extracellular exosome GO:0098978 - glutamatergic synapse
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 894 Hs			1 1655
+	Hs
		555681 ACTN1_HUMAN (8-894): 0: 672: 79.48		SCRIB_HUMAN (1-1655): 0: 940: 100.00
+	Hs
		1061514 ACTN3_HUMAN (25-894): 0: 645: 81.03		SCRIB_HUMAN (1-1655): 0: 940: 100.00
+	Hs
		224708 ACTN4_HUMAN (18-894): 0: 635: 77.89		SCRIB_HUMAN (1-1655): 0: 940: 100.00
+	Mm
		50271 A1BN54_MOUSE (8-894): 0: 674: 80.16		DLG4_MOUSE (812-1187): 1.23e-48: 188: 22.42
+	Hs
		773726 ACTN2_HUMAN (1-894): 0: 665: 100.00		DLG4_HUMAN (812-1187): 5.87e-49: 189: 22.42
+	Mm
		945621 ACTN4_MOUSE (18-894): 0: 632: 77.66		DLG4_MOUSE (812-1187): 1.23e-48: 188: 22.42
+	Hs
		773734 ACTN2_HUMAN (1-894): 0: 665: 100.00		DLG1_HUMAN (687-910): 5.8e-15: 82.9: 24.68
+	Hs
		555744 ACTN1_HUMAN (8-894): 0: 672: 79.48		ERBIN_HUMAN (541-949): 3.85e-10: 67.1: 13.27
+	Hs
		773776 ACTN2_HUMAN (1-894): 0: 665: 100.00		ERBIN_HUMAN (541-949): 3.85e-10: 67.1: 13.27
+	Dm
		1171759 Q9VZQ3_DROME (40-552): 6.89e-102: 351: 40.64		FLII_DROME (104-466): 2.09e-72: 268: 22.56
+	Dm
		1028078 SPTCB_DROME (269-624): 5.21e-09: 62.4: 12.92		FLII_DROME (104-466): 2.09e-72: 268: 22.56
+	Mm
		1223545 SPTB2_MOUSE (190-869): 4.28e-13: 75.8: 10.94		DLG4_MOUSE (812-1187): 1.23e-48: 188: 22.42
+	Hs
		1028850 SPTB2_HUMAN (190-869): 6.12e-13: 75.4: 10.80		LRRC7_HUMAN (816-951): 5.37e-09: 63.6: 27.54