Protein: ACTN4
Alpha-actinin-4 (Non-muscle alpha-actinin 4)

Gene: ACTN4
Organism: Mus musculus
Interactions: 36
UniProt ID: P57780

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0003713 - transcription coactivator activity
GO:0005200 - structural constituent of cytoskeleton
GO:0005509 - calcium ion binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

945616

MILK2
MICAL-like protein 2

1

15

Small-scale

0.715

High

811939

ZO1
Tight junction protein 1

1

13

Small-scale

0.665

High

945615

MYH6
Myosin-6

1

10

High-throughput

0.618

High

945617

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

4

High-throughput

0.536

High

945619

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

20

High-throughput

0.536

High

945626

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

3

High-throughput

0.536

High

945631

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.517

High

713192

NOS2
Nitric oxide synthase, inducible

1

2

Small-scale

0.515

High

945630

ALMS1
Centrosome-associated protein ALMS1

1

10

Small-scale

0.506

High

478504

ITB1
Integrin beta-1

1

12

High-throughput

0.501

High

945634

RAVR1
Ribonucleoprotein PTB-binding 1

1

1

Small-scale

0.481

High

895996

VATA
V-type proton ATPase catalytic subunit A

1

1

Small-scale

0.479

High

945613

TRAF6
TNF receptor-associated factor 6

1

14

Small-scale

0.479

High

945618

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

3

High-throughput

0.479

High

945620

SC6A4
Sodium-dependent serotonin transporter

1

3

High-throughput

0.479

High

945622

NEB2
Neurabin-2

1

20

High-throughput

0.479

High

945623

SPOP
Speckle-type POZ protein

1

2

High-throughput

0.479

High

945624

FACD2
Fanconi anemia group D2 protein homolog

1

5

High-throughput

0.479

High

945628

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.479

High

945632

EED
Polycomb protein EED

1

5

High-throughput

0.479

High

945633

NRX1A
Neurexin-1

1

9

High-throughput

0.479

High

915267

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

0

High-throughput

0.458

High

945627

CBAR1
CBY1-interacting BAR domain-containing protein 1

1

0

High-throughput

0.458

High

508997

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

1

3

High-throughput

0.457

High

148163

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

3

High-throughput

0.445

High

204789

ST2B1
Sulfotransferase 2B1

1

1

Small-scale

0.445

High

467750

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.445

High

905792

CAV3
Caveolin-3

1

7

High-throughput

0.445

High

945621

DLG4
Disks large homolog 4

1

13

High-throughput

0.445

High

945629

DNM1L
Dynamin-1-like protein

1

6

High-throughput

0.445

High

945635

SRCN1
SRC kinase signaling inhibitor 1

1

5

High-throughput

0.445

High

97574

E9PV60
WD repeat and FYVE domain containing 4

1

5

High-throughput

0.437

High

398208

CFAD
Complement factor D

1

8

High-throughput

0.437

High

945625

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

14

High-throughput

0.437

High

771695

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

4

High-throughput

0.407

High

945614

THIOM
Thioredoxin, mitochondrial

1

2

High-throughput

0.407

High


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Last updated: 11Aug2025