HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29845934, 29884807
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	La~RRM_1, RRM_1~RRM_1, RRM_1~zf-RanBP
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008380 - RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 582
+	Hs
		1194258 RBP56_HUMAN (42-460): 2.96e-42: 161: 48.10		LARP7_HUMAN (1-582): 4.06e-128: 389: 100.00
+	Hs
		1033005 EWS_HUMAN (3-451): 4.67e-30: 126: 31.05		LARP7_HUMAN (1-582): 4.06e-128: 389: 100.00
+	Hs
		1194492 RBM8A_HUMAN (219-366): 3.36e-27: 109: 26.35		LARP7_HUMAN (1-582): 4.06e-128: 389: 100.00
+	Hs
		1102042 RBP56_HUMAN (42-460): 2.96e-42: 161: 48.10		PABP4_HUMAN (1-208): 3.12e-41: 160: 11.98
+	Hs
		550392 RBP56_HUMAN (42-460): 2.96e-42: 161: 48.10		PABP1_HUMAN (1-405): 7.87e-41: 158: 10.29
+	Hs
		775060 FUS_HUMAN (1-526): 5.12e-39: 150: 100.00		PABP4_HUMAN (1-208): 3.12e-41: 160: 11.98
+	Hs
		550147 FUS_HUMAN (1-526): 5.12e-39: 150: 100.00		PABP1_HUMAN (1-405): 7.87e-41: 158: 10.29
+	Hs
		431095 EWS_HUMAN (3-451): 4.67e-30: 126: 31.05		LA_HUMAN (24-365): 5.99e-44: 163: 18.83
+	Hs
		431278 PPIE_HUMAN (280-514): 2.72e-31: 124: 19.84		LA_HUMAN (24-365): 5.99e-44: 163: 18.83
+	Hs
		550522 PPIE_HUMAN (280-514): 2.72e-31: 124: 19.84		PABP1_HUMAN (1-405): 7.87e-41: 158: 10.29
+	Hs
		1102145 RBM8A_HUMAN (219-366): 3.36e-27: 109: 26.35		PABP4_HUMAN (1-208): 3.12e-41: 160: 11.98
+	Hs
		550546 RBM8A_HUMAN (219-366): 3.36e-27: 109: 26.35		PABP1_HUMAN (1-405): 7.87e-41: 158: 10.29
+	Hs
		1259182 RBM8A_HUMAN (219-366): 3.36e-27: 109: 26.35		LARP4_HUMAN (22-216): 3.24e-40: 157: 21.32
+	Hs
		1365710 RBM8A_HUMAN (219-366): 3.36e-27: 109: 26.35		LAR4B_HUMAN (2-216): 8.51e-36: 145: 17.02
+	Hs
		1245683 RBP56_HUMAN (42-460): 2.96e-42: 161: 48.10		LARP1_HUMAN (29-114): 6.38e-13: 73.8: 40.23
+	Hs
		1152570 RBP56_HUMAN (42-460): 2.96e-42: 161: 48.10		ELAV1_HUMAN (92-211): 7.75e-13: 71.9: 22.50
+	Hs
		775157 FUS_HUMAN (1-526): 5.12e-39: 150: 100.00		LARP1_HUMAN (29-114): 6.38e-13: 73.8: 40.23
+	Hs
		775112 FUS_HUMAN (1-526): 5.12e-39: 150: 100.00		ELAV1_HUMAN (92-211): 7.75e-13: 71.9: 22.50
+	Hs
		1032992 EWS_HUMAN (3-451): 4.67e-30: 126: 31.05		ELAV1_HUMAN (92-211): 7.75e-13: 71.9: 22.50
+	Hs
		1245781 RBM8A_HUMAN (219-366): 3.36e-27: 109: 26.35		LARP1_HUMAN (29-114): 6.38e-13: 73.8: 40.23