HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: NUMB (P49757)
Protein numb homolog (h-Numb) (Protein S171)
Gene: NUMB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	37219487, 10953014, 9303539, 23211419
Identification Methods	unspecified method, affinity chromatography technology, phage display, coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0045296 - cadherin binding GO:0098978 - glutamatergic synapse
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 896 Hs			1 651
+	Mm
		788008 EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54		NUMB_MOUSE (1-651): 8.07e-101: 323: 92.96
+	Hs
		787894 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		DAB2_HUMAN (31-643): 9.53e-33: 136: 14.01
+	Mm
		787999 EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54		DAB2_MOUSE (5-598): 3.19e-36: 147: 13.49
+	Rn
		1126747 Q5JC29_RAT (1-774): 7.44e-120: 384: 88.79		SYNJ1_RAT (313-650): 6.99e-09: 61.4: 11.77
+	Hs
		833668 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		NUMB_HUMAN (1-651): 7.18e-103: 328: 100.00
+	Mm
		1206702 ITSN1_MOUSE (2-737): 1.82e-38: 158: 11.80		ANS1B_MOUSE (7-213): 4.87e-48: 184: 18.75
+	Dm
		112569 M9ND00_DROME (3-680): 3.38e-47: 184: 16.43		NUMB_DROME (16-540): 1.63e-40: 157: 36.14
+	Mm
		957157 ITSN1_MOUSE (2-737): 1.82e-38: 158: 11.80		DAB2_MOUSE (5-598): 3.19e-36: 147: 13.49
+	Hs
		269148 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		DAB1_HUMAN (31-622): 1.27e-34: 141: 15.66
+	Hs
		957186 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		DAB2_HUMAN (31-643): 9.53e-33: 136: 14.01
+	Dm
		91154 E3CTP7_DROME (10-209): 3.99e-30: 129: 43.27		NUMB_DROME (16-540): 1.63e-40: 157: 36.14
+	Ce
		1353620 Q9U2T9_CAEEL (5-425): 1.07e-23: 109: 11.85		NUMB1_CAEEL (1-539): 6.75e-43: 165: 28.52
+	Ce
		60780 Q9U2T9_CAEEL (5-425): 1.07e-23: 109: 11.85		A5JYR4_CAEEL (10-460): 6.7e-37: 146: 14.32
+	Ce
		283754 Q9U2T9_CAEEL (5-425): 1.07e-23: 109: 11.85		CED6_CAEEL (7-402): 5.6e-36: 143: 14.85
+	Mm
		1141842 EP15R_MOUSE (417-895): 9.06e-11: 67.9: 12.27		ANS1B_MOUSE (7-213): 4.87e-48: 184: 18.75
+	Ce
		60778 Q8WSP1_CAEEL (117-215): 2.67e-20: 98.2: 50.51		A5JYR4_CAEEL (10-460): 6.7e-37: 146: 14.32
+	Dm
		561284 Q8T8W3_DROME (239-313): 2.74e-09: 62.8: 42.67		NUMB_DROME (16-540): 1.63e-40: 157: 36.14
+	Mm
		957141 EP15R_MOUSE (417-895): 9.06e-11: 67.9: 12.27		DAB2_MOUSE (5-598): 3.19e-36: 147: 13.49