HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	34079125, 33961781, 35271311, 19380743
Identification Methods	proximity labelling technology, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0098794 - postsynapse GO:0098884 - postsynaptic neurotransmitter receptor internalization and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 896 Hs			1 937
+	Hs
		787903 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Mm
		788007 EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54		AP2B1_MOUSE (1-937): 0: 926: 99.89
+	Rn
		923853 Q5JC29_RAT (1-774): 7.44e-120: 384: 88.79		AP2B1_RAT (1-937): 0: 926: 100.00
+	Hs
		926031 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		321504 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Hs
		1014096 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		302112 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		AP2A2_HUMAN (11-933): 0: 600: 16.99
+	Hs
		925876 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		925895 FKB15_HUMAN (76-873): 1.31e-37: 154: 11.35		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Rn
		923861 ITSN1_RAT (11-737): 4.81e-34: 143: 12.14		AP2B1_RAT (1-937): 0: 926: 100.00
+	Hs
		1014017 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		212604 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		AP1G1_HUMAN (11-808): 1.03e-173: 527: 17.57
+	Mm
		567515 EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54		AP2A2_MOUSE (11-932): 0: 596: 16.50
+	Rn
		88764 Q5JC29_RAT (1-774): 7.44e-120: 384: 88.79		D3ZUY8_RAT (11-932): 0: 625: 17.14
+	Rn
		1126749 Q5JC29_RAT (1-774): 7.44e-120: 384: 88.79		Q66HM2_RAT (11-932): 0: 590: 16.38
+	Hs
		321552 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Rn
		88768 ITSN1_RAT (11-737): 4.81e-34: 143: 12.14		D3ZUY8_RAT (11-932): 0: 625: 17.14
+	Hs
		302157 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		AP2A2_HUMAN (11-933): 0: 600: 16.99
+	Dm
		91156 E3CTP7_DROME (10-209): 3.99e-30: 129: 43.27		AP2A_DROME (11-931): 0: 573: 16.72
+	Ce
		1094946 Q9U2T9_CAEEL (5-425): 1.07e-23: 109: 11.85		Q22601_CAEEL (9-626): 7.54e-140: 442: 20.26