HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: NECP2 (Q9NVZ3)
Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2)
Gene: NECAP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	35271311, 19380743
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0006897 - endocytosis GO:0015031 - protein transport
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 896 Hs			1 263
+	Hs
		787951 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		NECP1_HUMAN (3-263): 7.91e-142: 400: 61.96
+	Rn
		1126750 Q5JC29_RAT (1-774): 7.44e-120: 384: 88.79		NECP2_RAT (1-263): 1.56e-147: 414: 88.35
+	Rn
		935891 Q5JC29_RAT (1-774): 7.44e-120: 384: 88.79		NECP1_RAT (3-263): 2.51e-137: 389: 59.71
+	Hs
		1078917 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		NECP2_HUMAN (1-263): 6.93e-160: 446: 100.00
+	Hs
		1347010 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		NECP2_HUMAN (1-263): 6.93e-160: 446: 100.00