HitPredict

Interactor 1: ABL2 (P42684)
Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)
Gene: ABL2

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	1.00	0.527

Property	Details
Experiments	22974441
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1182 Hs			1 481
+	Hs
		337542 ABL1_HUMAN (58-1182): 0: 784: 51.21		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Mm
		337623 ABL1_MOUSE (58-1182): 0: 786: 51.24		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Mm
		337639 ABL1_MOUSE (58-1182): 0: 786: 51.24		DOK3_MOUSE (1-458): 4.81e-120: 360: 30.90
+	Mm
		250948 ABL1_MOUSE (58-1182): 0: 786: 51.24		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Hs
		235031 ABL1_HUMAN (58-1182): 0: 784: 51.21		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		433460 YES_HUMAN (21-556): 0: 551: 38.14		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		523124 SRC_HUMAN (24-556): 0: 549: 38.12		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		442876 HCK_HUMAN (36-554): 5.53e-177: 532: 36.96		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		454844 FGR_HUMAN (32-556): 2.64e-175: 528: 38.32		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Mm
		250949 SRC_MOUSE (24-556): 0: 551: 38.01		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Hs
		235037 YES_HUMAN (21-556): 0: 551: 38.14		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		235040 SRC_HUMAN (24-556): 0: 549: 38.12		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		235036 FYN_HUMAN (42-556): 0: 547: 38.91		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		235035 LCK_HUMAN (56-554): 7.83e-175: 526: 38.87		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		151689 LCK_HUMAN (56-554): 7.83e-175: 526: 38.87		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		412057 FYN_HUMAN (42-556): 0: 547: 38.91		IRS1_HUMAN (6-373): 1.95e-76: 262: 16.33
+	Dm
		1360394 SRC42_DROME (50-554): 0: 542: 40.63		Q9W3R6_DROME (1-256): 8.47e-59: 206: 25.75
+	Mm
		403453 SRC_MOUSE (24-556): 0: 551: 38.01		FRS2_MOUSE (154-464): 4.46e-56: 196: 21.73
+	Hs
		207290 HCK_HUMAN (36-554): 5.53e-177: 532: 36.96		FRS3_HUMAN (153-432): 4e-52: 185: 20.42
+	Hs
		411805 LCK_HUMAN (56-554): 7.83e-175: 526: 38.87		FRS2_HUMAN (154-464): 2.53e-54: 191: 21.09