Interactor 1: CDN2B (P42772)
Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)
Gene: CDKN2B
Interactor 2: CDK6 (Q00534)
Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)
Gene: CDK6
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.96 | 1.00 | 0.985 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26578655, 10022865, 28205554, 25416956, 26186194, 28514442, 32296183, 33961781, 32707033, 23602568, unassigned1304 |
| Identification Methods | fluorescent resonance energy transfer, affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach, tandem affinity purification, validated two hybrid, bimolecular fluorescence complementation |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Ank_2~Pkinase |
| Common GO terms | GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008285 - negative regulation of cell population proliferation GO:0050680 - negative regulation of epithelial cell proliferation |
| Homologous interactions | 16 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
