HitPredict

Interactor 1: CDN2B (P42772)
Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)
Gene: CDKN2B

Interactor 2: MP2K5 (Q13163)
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
Gene: MAP2K5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~Pkinase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 138 Hs			1 448
+	Hs
		790761 CDN2A_HUMAN (9-137): 9.34e-55: 170: 81.96		MP2K5_HUMAN (1-448): 4.77e-153: 443: 100.00
+	Hs
		790970 CDN2C_HUMAN (18-137): 2.41e-39: 131: 44.17		MP2K5_HUMAN (1-448): 4.77e-153: 443: 100.00
+	Hs
		681716 CDN2A_HUMAN (9-137): 9.34e-55: 170: 81.96		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		160430 CDN2A_HUMAN (9-137): 9.34e-55: 170: 81.96		AURKA_HUMAN (67-439): 1.27e-122: 364: 21.12
+	Hs
		681717 CDN2B_HUMAN (1-138): 2.59e-45: 145: 100.00		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		681718 CDN2C_HUMAN (18-137): 2.41e-39: 131: 44.17		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		790753 CDN2A_HUMAN (9-137): 9.34e-55: 170: 81.96		MP2K1_HUMAN (139-448): 1.69e-102: 312: 40.57
+	Hs
		647934 ANKR7_HUMAN (1-106): 5e-23: 92: 20.56		MARK3_HUMAN (113-430): 1.45e-116: 359: 20.49
+	Hs
		647851 DAPK1_HUMAN (1-99): 9.82e-20: 85.8: 20.00		MARK3_HUMAN (113-430): 1.45e-116: 359: 20.49
+	Hs
		862065 DAPK1_HUMAN (1-99): 9.82e-20: 85.8: 20.00		MARK2_HUMAN (113-445): 4.08e-116: 359: 20.59
+	Zm
		41209 A0A1D6NHI0_MAIZE (18-138): 1.11e-31: 120: 21.05		A0A1D6NVH8_MAIZE (137-433): 1.9e-103: 313: 36.18
+	Hs
		647932 ASB13_HUMAN (82-137): 1.26e-10: 59.2: 26.79		MARK3_HUMAN (113-430): 1.45e-116: 359: 20.49
+	Hs
		1026185 HACE1_HUMAN (52-138): 2.31e-19: 84.7: 28.74		PAK1_HUMAN (94-420): 7.29e-104: 321: 28.11
+	Hs
		276171 PSD10_HUMAN (53-137): 1.49e-17: 77.3: 15.29		MP2K1_HUMAN (139-448): 1.69e-102: 312: 40.57
+	Hs
		1264911 CTTB2_HUMAN (79-138): 4.51e-10: 58.1: 14.89		STK26_HUMAN (155-421): 7.86e-106: 321: 35.66
+	Hs
		131594 CTTB2_HUMAN (79-138): 4.51e-10: 58.1: 14.89		STK25_HUMAN (163-424): 1.64e-105: 321: 35.58
+	Hs
		790918 CDN2B_HUMAN (1-138): 2.59e-45: 145: 100.00		MP2K6_HUMAN (113-418): 1.74e-69: 225: 42.68
+	Hs
		790917 CDN2B_HUMAN (1-138): 2.59e-45: 145: 100.00		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09
+	Hs
		790958 CDN2C_HUMAN (18-137): 2.41e-39: 131: 44.17		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09
+	Hs
		257579 ANR17_HUMAN (3-86): 3e-13: 67.3: 24.72		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09