HitPredict

Interactor 1: HD (P42858)
Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]
Gene: HTT

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 0.60 0.699

The method score is based on:

Property Details
Experiments 25686248, 25311206, 20417604, 26637326
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005770 - late endosome
GO:0005776 - autophagosome
GO:0005783 - endoplasmic reticulum
and 4 others

more...
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 3142
Hs

1 440
+ Mm
+ Mm
+ Hs
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024