HitPredict

Interactor 1: GRK6 (P43250)
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
Gene: GRK6

Interactor 2: RUFY1 (Q96T51)
RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12)
Gene: RUFY1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 576 Hs			1 708
+	Hs
		714484 GRK5_HUMAN (1-563): 1.85e-175: 510: 71.76		MYH10_HUMAN (79-535): 1.05e-19: 96.6: 12.18
+	Hs
		714483 GRK5_HUMAN (1-563): 1.85e-175: 510: 71.76		MYH9_HUMAN (362-667): 1.39e-14: 80.1: 15.66
+	Mm
		554901 KPCE_MOUSE (11-507): 3.24e-148: 445: 24.28		MYH6_MOUSE (76-587): 9.28e-21: 100: 11.26
+	Mm
		554927 KPCE_MOUSE (11-507): 3.24e-148: 445: 24.28		MYH7_MOUSE (76-577): 7.81e-21: 100: 11.09
+	Hs
		724784 KPCE_HUMAN (11-507): 2.06e-147: 444: 24.09		MYH9_HUMAN (362-667): 1.39e-14: 80.1: 15.66
+	Hs
		626651 ARBK1_HUMAN (2-541): 2.79e-147: 442: 36.59		MRCKA_HUMAN (386-662): 9.1e-15: 80.6: 13.27
+	Hs
		522538 KAPCB_HUMAN (144-500): 4.26e-143: 419: 29.69		MYH1_HUMAN (76-572): 1.23e-21: 102: 9.58
+	Hs
		528359 KAPCB_HUMAN (144-500): 4.26e-143: 419: 29.69		MYH6_HUMAN (76-588): 6.87e-21: 100: 11.24
+	Hs
		568568 KAPCA_HUMAN (144-500): 5.83e-144: 421: 28.85		MYH10_HUMAN (79-535): 1.05e-19: 96.6: 12.18
+	Hs
		610802 KAPCB_HUMAN (144-500): 4.26e-143: 419: 29.69		MYH4_HUMAN (93-565): 9.53e-20: 97: 10.95
+	Hs
		610795 KAPCB_HUMAN (144-500): 4.26e-143: 419: 29.69		MYH2_HUMAN (73-516): 2.3e-18: 92.4: 9.23
+	Hs
		551672 KPCE_HUMAN (11-507): 2.06e-147: 444: 24.09		DESP_HUMAN (328-650): 9.91e-10: 64.5: 13.41
+	Hs
		681696 AKT1_HUMAN (75-497): 3.54e-143: 424: 30.59		MYH9_HUMAN (362-667): 1.39e-14: 80.1: 15.66
+	Hs
		568567 KAPCA_HUMAN (144-500): 5.83e-144: 421: 28.85		MYH9_HUMAN (362-667): 1.39e-14: 80.1: 15.66
+	Mm
		682109 AKT1_MOUSE (75-497): 2.96e-144: 427: 30.59		GRDN_MOUSE (312-647): 1.9e-09: 63.3: 15.54
+	Dm
		397193 KPC1_DROME (137-498): 2.17e-126: 388: 34.34		MYSN_DROME (210-666): 1.6e-21: 102: 14.90
+	Hs
		551616 AKT1_HUMAN (75-497): 3.54e-143: 424: 30.59		DESP_HUMAN (328-650): 9.91e-10: 64.5: 13.41
+	Hs
		681881 AKT1_HUMAN (75-497): 3.54e-143: 424: 30.59		GRDN_HUMAN (312-647): 7.56e-09: 61.4: 16.95
+	Mm
		1130947 AKT2_MOUSE (75-496): 8.48e-142: 420: 30.12		GRDN_MOUSE (312-647): 1.9e-09: 63.3: 15.54
+	Hs
		568689 KAPCA_HUMAN (144-500): 5.83e-144: 421: 28.85		GRDN_HUMAN (312-647): 7.56e-09: 61.4: 16.95