HitPredict

Interactor 1: ATG8 (P38182)
Autophagy-related protein 8 (Autophagy-related ubiquitin-like modifier ATG8) (Cytoplasm to vacuole targeting protein 5)
Gene: ATG8

Interactor 2: ATG4 (P53867)
Cysteine protease ATG4 (EC 3.4.22.-) (Autophagy-related protein 4)
Gene: ATG4

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.975

The method score is based on:

Property Details
Experiments 9649430, 28821724, 28330855, 28287329, 18719252, 25483965, 11038174, 18971623
Identification Methods affinity chromatography technology, two hybrid, pull down, enzymatic study
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains ATG8~Peptidase_C54
Common GO terms GO:0000045 - autophagosome assembly
GO:0000407 - phagophore assembly site
GO:0000422 - autophagy of mitochondrion
GO:0000423 - mitophagy
GO:0005737 - cytoplasm
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 117
Sc

1 494
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+ Ce

Service provided by Combinatics, Japan

Last updated: 11Aug2025