Protein: ATG4C
Cysteine protease ATG4C (EC 3.4.22.-) (AUT-like 3 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 3) (Autophagin-3) (Autophagy-related protein 4 homolog C) (HsAPG4C)

Gene: ATG4C
Organism: Homo sapiens
Interactions: 42
UniProt ID: Q96DT6

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000423 - mitophagy
GO:0004197 - cysteine-type endopeptidase activity
GO:0005737 - cytoplasm
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1287349

ATG4D
Cysteine protease ATG4D

1

2

High-throughput

0.691

High

1387821

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.691

High

328106

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

20

Small-scale

0.647

High

1387820

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

20

Small-scale

0.647

High

1349049

R3GEF
Guanine nucleotide exchange factor for Rab-3A

3

0

High-throughput

0.638

High

1199636

KLH22
Kelch-like protein 22

2

0

High-throughput

0.602

High

1387815

ATG4C
Cysteine protease ATG4C

1

2

High-throughput

0.575

High

778751

PRS7
26S proteasome regulatory subunit 7

1

2

High-throughput

0.536

High

851389

PRS6B
26S proteasome regulatory subunit 6B

1

2

High-throughput

0.536

High

907530

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.536

High

969019

PRS8
26S proteasome regulatory subunit 8

1

3

High-throughput

0.536

High

243996

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

0

High-throughput

0.513

High

1279215

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.513

High

1387818

ALS2
Alsin

1

0

High-throughput

0.513

High

843849

HD
Huntingtin

1

0

High-throughput

0.493

High

871996

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

2

High-throughput

0.489

High

968781

PRS4
26S proteasome regulatory subunit 4

1

2

High-throughput

0.489

High

1006160

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

2

High-throughput

0.489

High

1130147

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

High-throughput

0.489

High

1246142

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

1

High-throughput

0.489

High

1349209

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

2

High-throughput

0.489

High

1387823

VP33B
Vacuolar protein sorting-associated protein 33B

1

1

High-throughput

0.479

High

975175

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

562304

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.437

High

1383640

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.437

High

1387824

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.437

High

1227232

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

133681

WASL
Actin nucleation-promoting factor WASL

2

0

High-throughput

0.328

High

479745

GSTA2
Glutathione S-transferase A2

2

0

High-throughput

0.328

High

184895

SPTC1
Serine palmitoyltransferase 1

1

0

High-throughput

0.279

Low

907766

CLCN6
H(+)/Cl(-) exchange transporter 6

1

0

High-throughput

0.279

Low

1008283

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

High-throughput

0.279

Low

1098090

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.279

Low

1206877

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.279

Low

1249629

PXDC2
Plexin domain-containing protein 2

1

0

High-throughput

0.279

Low

1387816

ZHX1R
Zinc fingers and homeoboxes protein 1, isoform 2

1

0

High-throughput

0.279

Low

1387817

SYNM
Asparaginyl-tRNA synthetase

1

0

High-throughput

0.279

Low

1387819

GCP5
Gamma-tubulin complex component 5

1

0

High-throughput

0.279

Low

1387822

SMG9
Nonsense-mediated mRNA decay factor SMG9

1

0

High-throughput

0.279

Low

946854

H2B1D
Histone H2B type 1-D

1

0

High-throughput

0.249

Low

1233410

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025