Protein: BACE1
Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)

Gene: BACE1
Organism: Homo sapiens
Interactions: 50
UniProt ID: P56817

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0004175 - endopeptidase activity
GO:0004190 - aspartic-type endopeptidase activity
GO:0005764 - lysosome
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

394423

A4
Amyloid-beta precursor protein

8

2

Small-scale

0.746

High

882053

GGA1
ADP-ribosylation factor-binding protein GGA1

5

5

Small-scale

0.733

High

882051

GGA3
ADP-ribosylation factor-binding protein GGA3

2

4

Small-scale

0.646

High

882052

GGA2
ADP-ribosylation factor-binding protein GGA2

2

5

Small-scale

0.646

High

882054

FBX2
F-box only protein 2

1

2

Small-scale

0.561

High

882055

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

Small-scale

0.537

High

882058

HYOU1
Hypoxia up-regulated protein 1

1

0

Small-scale

0.537

High

307010

RTN3
Reticulon-3

1

2

Small-scale

0.536

High

644554

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

5

High-throughput

0.536

High

882033

NKG2E
NKG2-E type II integral membrane protein

1

4

High-throughput

0.536

High

882050

RTN4
Reticulon-4

1

2

Small-scale

0.536

High

882049

TMX1
Thioredoxin-related transmembrane protein 1

2

2

Small-scale

0.521

High

834254

PSN1
Presenilin-1

1

0

Small-scale

0.519

High

428990

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.518

High

882041

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

0

Small-scale

0.513

High

882032

KCNC4
Potassium voltage-gated channel subfamily C member 4

1

0

Small-scale

0.512

High

501600

IAPP
Islet amyloid polypeptide

1

1

Small-scale

0.501

High

777021

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

Small-scale

0.501

High

882057

ITM2B
Integral membrane protein 2B

1

0

Small-scale

0.493

High

882042

NICA
Nicastrin

1

0

Small-scale

0.480

High

882056

SNX6
Sorting nexin-6

1

0

Small-scale

0.479

High

850262

KCNQ1
Potassium voltage-gated channel subfamily KQT member 1

1

1

Small-scale

0.479

High

882035

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

Small-scale

0.479

High

882045

RANB9
Ran-binding protein 9

1

1

Small-scale

0.479

High

882046

SORT
Sortilin

1

1

Small-scale

0.479

High

313681

BRI3
Membrane protein BRI3

1

0

Small-scale

0.458

High

436614

TNR16
Tumor necrosis factor receptor superfamily member 16

1

0

Small-scale

0.458

High

882036

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

1

0

Small-scale

0.458

High

882044

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.458

High

152268

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

1

Small-scale

0.457

High

423190

PDIA1
Protein disulfide-isomerase

1

3

Small-scale

0.445

High

501886

BIP
Endoplasmic reticulum chaperone BiP

1

2

Small-scale

0.445

High

614287

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

Small-scale

0.445

High

636871

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

Small-scale

0.445

High

653532

CALR
Calreticulin

1

3

Small-scale

0.445

High

654210

CALX
Calnexin

1

3

Small-scale

0.445

High

671767

PDIA3
Protein disulfide-isomerase A3

1

3

Small-scale

0.445

High

882031

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

Small-scale

0.445

High

882034

FLOT2
Flotillin-2

1

2

Small-scale

0.445

High

882039

TBA1A
Tubulin alpha-1A chain

1

3

Small-scale

0.445

High

397328

ADT2
ADP/ATP translocase 2

1

0

Small-scale

0.426

High

838612

GDIB
Rab GDP dissociation inhibitor beta

1

0

Small-scale

0.426

High

882037

IMB1
Importin subunit beta-1

1

0

Small-scale

0.426

High

882048

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

0

Small-scale

0.426

High

882047

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

2

Small-scale

0.407

High

882038

SG1D4
Secretoglobin family 1D member 4

2

0

High-throughput

0.328

High

269304

SG2A1
Mammaglobin-B

1

0

High-throughput

0.279

Low

882043

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.249

Low

64230

TBB8B
Tubulin beta 8B

1

0

Small-scale

0.232

Low

882040

TPPC5
Trafficking protein particle complex subunit 5

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024