HitPredict

Interactor 1: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Interactor 2: HAVR2 (Q8TDQ0)
Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
Gene: HAVCR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.39	0.60	0.484

Property	Details
Experiments	26492563
Identification Methods	anti bait coimmunoprecipitation, pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002250 - adaptive immune response GO:0002281 - macrophage activation involved in immune response GO:0032753 - positive regulation of interleukin-4 production GO:0032760 - positive regulation of tumor necrosis factor production GO:0045087 - innate immune response
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 635 Hs			1 301
+	Hs
		796479 ZAP70_HUMAN (6-635): 0: 535: 53.57		HAVR2_HUMAN (1-301): 0: 542: 100.00
+	Hs
		411802 LCK_HUMAN (5-201): 3.03e-71: 240: 23.29		HAVR2_HUMAN (1-301): 0: 542: 100.00
+	Hs
		412276 FYN_HUMAN (4-201): 3.14e-69: 236: 22.03		HAVR2_HUMAN (1-301): 0: 542: 100.00
+	Hs
		383892 ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34		HAVR2_HUMAN (1-301): 0: 542: 100.00
+	Hs
		616843 JAK1_HUMAN (312-632): 4.51e-39: 156: 20.81		HAVR2_HUMAN (1-301): 0: 542: 100.00
+	Hs
		412298 FYN_HUMAN (4-201): 3.14e-69: 236: 22.03		HAVR1_HUMAN (10-133): 2.47e-51: 174: 40.95