HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: TBB4B (P68371)
Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain)
Gene: TUBB4B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26831064
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1863 Hs			1 445
+	Hs
		799083 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TBB3_HUMAN (1-443): 0: 714: 93.23
+	Hs
		457276 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		799449 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TBB6_HUMAN (1-432): 0: 706: 92.36
+	Hs
		799178 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TBB8_HUMAN (1-427): 0: 696: 91.10
+	Hs
		457592 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		997449 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		TBB4B_HUMAN (1-427): 0: 711: 100.00
+	Hs
		1364236 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		TBB2B_HUMAN (1-430): 0: 710: 98.14
+	Hs
		1118541 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		TBB2A_HUMAN (1-430): 0: 707: 97.67
+	Hs
		1364234 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		TBB6_HUMAN (1-432): 0: 706: 92.36
+	Hs
		1191921 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		TBB8_HUMAN (1-427): 0: 696: 91.10
+	Hs
		1108693 TRIM6_HUMAN (10-377): 7.06e-68: 240: 13.54		TBB3_HUMAN (1-443): 0: 714: 93.23
+	Hs
		457221 RO52_HUMAN (15-390): 5.97e-69: 243: 12.86		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		623267 RO52_HUMAN (15-390): 5.97e-69: 243: 12.86		TBB4B_HUMAN (1-427): 0: 711: 100.00
+	Hs
		407977 RO52_HUMAN (15-390): 5.97e-69: 243: 12.86		TBB4A_HUMAN (1-427): 0: 706: 98.60
+	Hs
		1118625 TRI10_HUMAN (12-342): 2.47e-55: 203: 13.97		TBB2A_HUMAN (1-430): 0: 707: 97.67
+	Hs
		1108692 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		TBB3_HUMAN (1-443): 0: 714: 93.23
+	Hs
		457678 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		997496 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		TBB4B_HUMAN (1-427): 0: 711: 100.00
+	Hs
		1118583 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		TBB2A_HUMAN (1-430): 0: 707: 97.67
+	Hs
		408154 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		TBB4A_HUMAN (1-427): 0: 706: 98.60