HitPredict

Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL

Interactor 2: ASAP1 (Q9ULH1)
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
Gene: ASAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1, PH~SH3_1, SH3_2~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 1129
+	Hs
		802771 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		ASAP1_HUMAN (17-1129): 0: 831: 100.00
+	Hs
		275240 GRAP2_HUMAN (4-291): 5.79e-36: 133: 14.97		ASAP1_HUMAN (17-1129): 0: 831: 100.00
+	Hs
		581076 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		ASAP1_HUMAN (17-1129): 0: 831: 100.00
+	Hs
		557823 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		ASAP1_HUMAN (17-1129): 0: 831: 100.00
+	Hs
		195788 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		ASAP2_HUMAN (21-967): 0: 647: 55.31
+	Hs
		802877 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		ASAP3_HUMAN (21-913): 7.03e-177: 544: 44.27
+	Hs
		195785 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		ASAP2_HUMAN (21-967): 0: 647: 55.31
+	Hs
		195783 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		ASAP2_HUMAN (21-967): 0: 647: 55.31
+	Hs
		195796 Q5JPT6_HUMAN (219-297): 1.64e-15: 78.7: 24.69		ASAP2_HUMAN (21-967): 0: 647: 55.31
+	Hs
		195804 SH3K1_HUMAN (219-297): 1.64e-15: 78.7: 24.69		ASAP2_HUMAN (21-967): 0: 647: 55.31
+	Hs
		802672 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		ASAP3_HUMAN (21-913): 7.03e-177: 544: 44.27
+	Hs
		557696 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		ACAP1_HUMAN (45-690): 2.77e-153: 477: 21.01
+	Rn
		499164 PLCG1_RAT (5-224): 2.46e-29: 119: 16.95		AGAP2_RAT (379-660): 5.08e-87: 308: 29.02
+	Hs
		802704 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		ARAP1_HUMAN (368-620): 3.83e-58: 222: 24.90
+	Hs
		63070 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		RHG42_HUMAN (760-1124): 2.05e-14: 80.3: 12.02
+	Hs
		557775 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		ARAP1_HUMAN (368-620): 3.83e-58: 222: 24.90
+	Hs
		1285175 SH3K1_HUMAN (219-297): 1.64e-15: 78.7: 24.69		ARAP1_HUMAN (368-620): 3.83e-58: 222: 24.90
+	Hs
		1262750 SH3K1_HUMAN (219-297): 1.64e-15: 78.7: 24.69		ARAP3_HUMAN (368-605): 4.78e-56: 215: 27.46
+	Hs
		557688 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		GIT2_HUMAN (446-1074): 4.12e-57: 213: 16.98
+	Hs
		63069 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		RHG42_HUMAN (760-1124): 2.05e-14: 80.3: 12.02