HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 0.60 0.720

The method score is based on:

Property Details
Experiments 15023535, 16061658, 12807903, 25283809, 19047365
Identification Methods two hybrid, pull down, affinity chromatography technology, isothermal titration calorimetry
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000976 - transcription cis-regulatory region binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0045893 - positive regulation of DNA-templated transcription
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 504
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024