HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30472188, 38223760
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 504 Hs			1 551
+	Hs
		125492 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1084573 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1084629 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1084614 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		125259 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93
+	Hs
		125581 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		125260 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		1235773 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		808408 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93
+	Hs
		1235798 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		125430 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		125122 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516643 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		125274 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		SC24C_HUMAN (233-440): 1.79e-12: 72.2: 17.05
+	Hs
		516402 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		125061 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		SC24D_HUMAN (131-353): 2.02e-11: 68.8: 21.49
+	Mm
		1208066 WWP2_MOUSE (1-504): 1.16e-129: 399: 15.68		DIDO1_MOUSE (151-446): 1.18e-09: 63.3: 17.16
+	Hs
		125687 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59
+	Hs
		125698 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Hs
		1311993 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59