Protein: AURK
Aurora kinase (EC 2.7.11.1) (Increase-in-ploidy protein 1) (Spindle assembly checkpoint kinase)

Gene: AURK, IPL1
Organism: Saccharomyces cerevisiae S288C
Interactions: 102
UniProt ID: P38991

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

797332

INCE
Inner centromere protein SLI15

14

0

Small-scale

0.936

High

808646

BIR1
Chromosomal passenger complex protein BIR1

6

0

Small-scale

0.899

High

364532

CDK1
Cyclin-dependent kinase 1

2

7

Small-scale

0.812

High

808627

AURK
Aurora kinase

2

14

Small-scale

0.768

High

808649

DAM1
DASH complex subunit DAM1

7

1

Small-scale

0.749

High

808632

BIM1
Protein BIM1

6

8

Small-scale

0.729

High

800795

RCK2
Serine/threonine-protein kinase RCK2

1

17

High-throughput

0.724

High

808673

ARP8
Actin-like protein ARP8

1

9

High-throughput

0.724

High

808663

RRP5
rRNA biogenesis protein RRP5

2

4

High-throughput

0.696

High

808655

H3
Histone H3

3

20

Small-scale

0.670

High

808635

NDC80
Kinetochore protein NDC80

3

20

Small-scale

0.667

High

808672

YRA1
RNA annealing protein YRA1

1

8

High-throughput

0.665

High

738748

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

4

0

Small-scale

0.662

High

548697

RNA1
Ran GTPase-activating protein 1

1

5

High-throughput

0.647

High

667088

CG22
G2/mitotic-specific cyclin-2

1

3

Small-scale

0.647

High

670706

SIS1
Protein SIS1

1

11

High-throughput

0.647

High

807069

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

11

High-throughput

0.647

High

808671

YP150
Putative serine/threonine-protein kinase YPL150W

1

17

High-throughput

0.647

High

735261

KNS1
Dual specificity protein kinase KNS1

1

14

High-throughput

0.621

High

808638

DSN1
Kinetochore-associated protein DSN1

3

0

Small-scale

0.619

High

808656

CDC14
Tyrosine-protein phosphatase CDC14

1

8

Small-scale

0.618

High

808629

YCFI
Metal resistance protein YCF1

1

0

High-throughput

0.614

High

734667

IMB3
Importin subunit beta-3

2

3

Small-scale

0.611

High

808676

NBL1
N-terminal-borealin-like protein

2

0

Small-scale

0.609

High

763740

CENPC
Inner kinetochore subunit MIF2

2

1

Small-scale

0.602

High

776692

ASK1
DASH complex subunit ASK1

2

0

Small-scale

0.577

High

781898

SPC34
DASH complex subunit SPC34

2

0

Small-scale

0.577

High

807187

IF1A
Eukaryotic translation initiation factor 1A

1

1

High-throughput

0.561

High

751535

YKJ1
CRAL-TRIO domain-containing protein YKL091C

1

0

High-throughput

0.537

High

808630

RV167
Reduced viability upon starvation protein 167

1

5

High-throughput

0.515

High

808666

IMB1
Importin subunit beta-1

1

3

High-throughput

0.515

High

394559

EF1A
Elongation factor 1-alpha

1

5

High-throughput

0.501

High

416238

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.501

High

432581

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.501

High

438692

SC160
Protein SCP160

1

11

High-throughput

0.501

High

448450

RAD52
DNA repair and recombination protein RAD52

1

1

Small-scale

0.501

High

584914

TRM1
tRNA

1

3

High-throughput

0.501

High

624460

RDS2
Regulator of drug sensitivity 2

1

1

High-throughput

0.501

High

670266

NAP1
Nucleosome assembly protein

1

5

High-throughput

0.501

High

724317

PUS3
tRNA pseudouridine(38/39) synthase

1

1

High-throughput

0.501

High

736486

MDHP
Malate dehydrogenase, peroxisomal

1

2

High-throughput

0.501

High

746626

DRS1
ATP-dependent RNA helicase DRS1

1

14

High-throughput

0.501

High

751262

CNS1
Hsp70/Hsp90 co-chaperone CNS1

1

7

High-throughput

0.501

High

757812

YBF5
Deoxyribonuclease Tat-D

1

1

High-throughput

0.501

High

779228

CENPA
Histone H3-like centromeric protein CSE4

1

20

Small-scale

0.501

High

781103

YKC3
Uncharacterized protein YKL023W

1

1

High-throughput

0.501

High

794114

FAT2
Oxalate--CoA ligase

1

1

High-throughput

0.501

High

803255

OTU2
OTU domain-containing protein 2

1

9

High-throughput

0.501

High

805121

YNG2
Chromatin modification-related protein YNG2

1

2

High-throughput

0.501

High

807884

BFR1
Nuclear segregation protein BFR1

1

1

High-throughput

0.501

High

808628

STM1
Suppressor protein STM1

1

1

High-throughput

0.501

High

808631

RSP5
E3 ubiquitin-protein ligase RSP5

1

15

High-throughput

0.501

High

808634

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

16

High-throughput

0.501

High

808637

DOT5
Peroxiredoxin DOT5

1

3

High-throughput

0.501

High

808639

SYA
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.501

High

808641

MVP1
Sorting nexin MVP1

1

8

High-throughput

0.501

High

808643

ARC1
tRNA-aminoacylation cofactor ARC1

1

2

High-throughput

0.501

High

808644

MAD3
Spindle assembly checkpoint component MAD3

1

2

Small-scale

0.501

High

808650

YG3A
Uncharacterized protein YGR130C

1

20

High-throughput

0.501

High

808653

VPS75
Vacuolar protein sorting-associated protein 75

1

4

High-throughput

0.501

High

808659

HAS1
ATP-dependent RNA helicase HAS1

1

13

High-throughput

0.501

High

808660

GLRX3
Monothiol glutaredoxin-3

1

4

High-throughput

0.501

High

808665

RGC1
Regulator of the glycerol channel 1

1

1

High-throughput

0.501

High

808670

CMS1
Protein CMS1

1

2

High-throughput

0.501

High

649493

UBA1
Ubiquitin-activating enzyme E1 1

1

0

High-throughput

0.493

High

751398

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.493

High

808633

YEY6
MYG1 protein YER156C

1

0

High-throughput

0.493

High

808668

PBP4
Protein PBP4

1

0

High-throughput

0.493

High

795799

SHE1
Mitotic spindle-associated protein SHE1

1

0

Small-scale

0.480

High

807216

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.480

High

808636

UTP25
U3 small nucleolar RNA-associated protein 25

1

0

High-throughput

0.480

High

808642

CENPT
Inner kinetochore subunit CNN1

1

0

Small-scale

0.480

High

808661

FIN1
Filament protein FIN1

1

0

Small-scale

0.480

High

745472

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

High-throughput

0.460

High

797242

HSL7
Protein arginine N-methyltransferase HSL7

1

0

High-throughput

0.460

High

808645

BFA1
Mitotic check point protein BFA1

1

0

High-throughput

0.460

High

808652

CENPQ
Inner kinetochore subunit OKP1

1

0

High-throughput

0.460

High

808654

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.460

High

797875

CENPU
Inner kinetochore subunit AME1

1

0

Small-scale

0.458

High

808648

DUO1
DASH complex subunit DUO1

1

0

Small-scale

0.458

High

808669

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

673565

NLE1
Ribosome assembly protein 4

1

11

High-throughput

0.457

High

798413

RGD1
RHO GTPase-activating protein RGD1

1

6

Small-scale

0.457

High

808640

YJV8
Putative acetyltransferase YJL218W

1

1

High-throughput

0.457

High

808658

FOX2
Peroxisomal hydratase-dehydrogenase-epimerase

1

2

High-throughput

0.457

High

808664

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

1

High-throughput

0.457

High

808674

MPD1
Protein disulfide-isomerase MPD1

1

4

High-throughput

0.457

High

808657

UBC7
Ubiquitin-conjugating enzyme E2 7

1

4

High-throughput

0.457

High

523947

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

544873

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

739634

SPT16
FACT complex subunit SPT16

1

5

High-throughput

0.437

High

808667

CND1
Condensin complex subunit 1

1

1

Small-scale

0.437

High

808662

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.426

High

744708

GPT1
Glycerol-3-phosphate O-acyltransferase 1

1

0

High-throughput

0.261

Low

745159

CACP
Carnitine O-acetyltransferase, mitochondrial

1

0

High-throughput

0.261

Low

745185

CDC13
Cell division control protein 13

1

0

Small-scale

0.261

Low

794858

MRX3
MIOREX complex component 3

1

0

High-throughput

0.261

Low

799737

YM8C
Uncharacterized deoxyribonuclease YMR262W

1

0

High-throughput

0.261

Low

808647

YD183
Uncharacterized protein YDL183C

1

0

High-throughput

0.261

Low

808651

YG3W
Uncharacterized protein YGR168C

1

0

High-throughput

0.261

Low

808675

LPX1
Peroxisomal membrane protein LPX1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025