HitPredict

Interactor 1: DYN1 (P39053)
Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)
Gene: Dnm1

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	23452850
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 867 Mm			1 217
+	Hs
		987565 DYN1_HUMAN (1-845): 0: 1050: 99.65		GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54
+	Rn
		638953 DYN1_RAT (1-845): 0: 1042: 98.34		GRB2_RAT (1-217): 4.48e-72: 219: 99.54
+	Mm
		1221239 DYN3_MOUSE (1-839): 0: 991: 78.96		GRB2_MOUSE (1-217): 1.59e-72: 220: 100.00
+	Mm
		810547 DYN2_MOUSE (1-845): 0: 985: 78.28		GRB2_MOUSE (1-217): 1.59e-72: 220: 100.00
+	Hs
		896723 DYN2_HUMAN (1-845): 0: 983: 77.93		GRB2_HUMAN (1-217): 4.48e-72: 219: 99.54
+	Hs
		896746 DYN2_HUMAN (1-845): 0: 983: 77.93		GRAP_HUMAN (1-213): 1.13e-63: 198: 56.74
+	Mm
		810542 DYN1_MOUSE (1-867): 0: 1086: 100.00		ITSN1_MOUSE (154-216): 3.11e-12: 67.3: 30.16
+	Hs
		593970 DYN1_HUMAN (1-845): 0: 1050: 99.65		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Hs
		362253 DYN1_HUMAN (1-845): 0: 1050: 99.65		ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46
+	Hs
		439999 DYN2_HUMAN (1-845): 0: 983: 77.93		LCK_HUMAN (3-202): 4.02e-36: 134: 27.49
+	Hs
		1050684 DYN1_HUMAN (1-845): 0: 1050: 99.65		ITSN1_HUMAN (123-216): 1.09e-11: 65.4: 23.76
+	Hs
		557244 DYN1_HUMAN (1-845): 0: 1050: 99.65		SRC_HUMAN (160-215): 2.32e-11: 64.2: 31.03
+	Rn
		638964 DYN1_RAT (1-845): 0: 1042: 98.34		ITSN1_RAT (154-216): 3.04e-11: 64.2: 30.16
+	Hs
		362214 DYN2_HUMAN (1-845): 0: 983: 77.93		ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46
+	Hs
		440447 DYN2_HUMAN (1-845): 0: 983: 77.93		FYN_HUMAN (161-215): 1.22e-13: 71.1: 31.58
+	Mm
		810562 DYN2_MOUSE (1-845): 0: 985: 78.28		ITSN1_MOUSE (154-216): 3.11e-12: 67.3: 30.16
+	Hs
		557180 DYN2_HUMAN (1-845): 0: 983: 77.93		SRC_HUMAN (160-215): 2.32e-11: 64.2: 31.03
+	Hs
		473383 DYN2_HUMAN (1-845): 0: 983: 77.93		HCK_HUMAN (116-215): 5.18e-11: 63.1: 19.61
+	Hs
		463408 DYN2_HUMAN (1-845): 0: 983: 77.93		LYN_HUMAN (135-215): 9.03e-11: 62.7: 24.10
+	Hs
		292819 DYN2_HUMAN (1-845): 0: 983: 77.93		GRAP2_HUMAN (3-55): 7.11e-11: 62.5: 39.62