HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: GRAP (Q13588)
GRB2-related adapter protein
Gene: GRAP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0098793 - presynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 217
+	Mm
		810547 DYN2_MOUSE (1-870): 0: 1057: 98.16		GRB2_MOUSE (1-216): 9.27e-70: 214: 59.72
+	Hs
		896723 DYN2_HUMAN (1-870): 0: 1057: 100.00		GRB2_HUMAN (1-216): 1.09e-69: 214: 59.72
+	Hs
		362214 DYN2_HUMAN (1-870): 0: 1057: 100.00		ABL1_HUMAN (3-180): 4.03e-52: 182: 31.69
+	Mm
		810522 DYN1_MOUSE (1-844): 0: 1003: 79.23		GRB2_MOUSE (1-216): 9.27e-70: 214: 59.72
+	Hs
		987565 DYN1_HUMAN (1-846): 0: 1002: 79.04		GRB2_HUMAN (1-216): 1.09e-69: 214: 59.72
+	Hs
		440447 DYN2_HUMAN (1-870): 0: 1057: 100.00		FYN_HUMAN (3-217): 2.02e-40: 146: 24.17
+	Hs
		439999 DYN2_HUMAN (1-870): 0: 1057: 100.00		LCK_HUMAN (4-204): 3.75e-35: 131: 26.05
+	Hs
		362253 DYN1_HUMAN (1-846): 0: 1002: 79.04		ABL1_HUMAN (3-180): 4.03e-52: 182: 31.69
+	Hs
		896907 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN2_HUMAN (2-62): 3.71e-14: 72.7: 34.43
+	Mm
		810562 DYN2_MOUSE (1-870): 0: 1057: 98.16		ITSN1_MOUSE (67-215): 1.27e-13: 71.1: 15.48
+	Hs
		896763 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN1_HUMAN (50-215): 6.01e-13: 69.2: 12.36
+	Hs
		292819 DYN2_HUMAN (1-870): 0: 1057: 100.00		GRAP2_HUMAN (3-55): 1.73e-11: 64: 33.96
+	Hs
		463408 DYN2_HUMAN (1-870): 0: 1057: 100.00		LYN_HUMAN (103-216): 6.81e-11: 63: 13.93
+	Hs
		473383 DYN2_HUMAN (1-870): 0: 1057: 100.00		HCK_HUMAN (81-215): 2.36e-10: 61.5: 18.98
+	Hs
		557180 DYN2_HUMAN (1-870): 0: 1057: 100.00		SRC_HUMAN (149-214): 3.66e-10: 60.7: 23.53
+	Hs
		593970 DYN1_HUMAN (1-846): 0: 1002: 79.04		NCK1_HUMAN (5-145): 1.05e-23: 99: 35.47
+	Mm
		237068 DYN1_MOUSE (1-844): 0: 1003: 79.23		NCK2_MOUSE (6-140): 3.1e-20: 89.4: 34.97
+	Mm
		810542 DYN1_MOUSE (1-844): 0: 1003: 79.23		ITSN1_MOUSE (67-215): 1.27e-13: 71.1: 15.48
+	Hs
		1050684 DYN1_HUMAN (1-846): 0: 1002: 79.04		ITSN1_HUMAN (50-215): 6.01e-13: 69.2: 12.36
+	Hs
		557244 DYN1_HUMAN (1-846): 0: 1002: 79.04		SRC_HUMAN (149-214): 3.66e-10: 60.7: 23.53