HitPredict

Interactor 1: LIMS1 (P48059)
LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48)
Gene: LIMS1

Interactor 2: ILK (Q13418)
Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (Beta-integrin-linked kinase) (ILK-1) (ILK-2) (p59ILK)
Gene: ILK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 26186194, 28514442, 19117955, 11331308, 23414517, 33961781, 10022929, 25852190, 26496610, 22767580, 26172215, 32296183, 31578224, 12167643, 35271311, 32707033, 36736316, 23455922, 19074270, 25416956 and 5 others

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Identification Methods affinity chromatography technology, x-ray crystallography, pull down, two hybrid, molecular sieving, mammalian protein protein interaction trap, anti tag coimmunoprecipitation, two hybrid array, validated two hybrid, two hybrid fragment pooling approach and 4 others

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Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Ank_2~LIM
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0019901 - protein kinase binding
GO:0033209 - tumor necrosis factor-mediated signaling pathway
and 2 others

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Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 325
Hs

1 452
+ Mm
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+ Ce
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+ Rn
+ Mm
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+ Hs
+ Dm
+ Hs
+ Mm
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+ Ce
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024