HitPredict

Interactor 1: CAP2 (P40123)
Adenylyl cyclase-associated protein 2 (CAP 2)
Gene: CAP2

Interactor 2: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.970

Property	Details
Experiments	25416956, 25910212, 34079125, 33961781, 35271311, 28514442, 38334954
Identification Methods	two hybrid, proximity labelling technology, affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation, split luciferase complementation, two hybrid bait and prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Actin~CAP_C, Actin~CAP_N
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007163 - establishment or maintenance of cell polarity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 477 Hs			1 375
+	Hs
		818799 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Hs
		506927 CAP2_HUMAN (1-477): 0: 698: 100.00		POTEI_HUMAN (1-375): 0: 731: 91.20
+	Hs
		1030734 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Hs
		506942 CAP1_HUMAN (1-475): 0: 651: 62.71		POTEI_HUMAN (1-375): 0: 731: 91.20
+	Hs
		818795 CAP2_HUMAN (1-477): 0: 698: 100.00		Q1KLZ0_HUMAN (1-375): 0: 603: 100.00
+	Hs
		818787 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		818788 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		818789 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTS_HUMAN (2-375): 0: 592: 93.58
+	Hs
		818786 CAP2_HUMAN (1-477): 0: 698: 100.00		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Hs
		952753 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		993137 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		995545 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		996429 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTS_HUMAN (2-375): 0: 592: 93.58
+	Hs
		977676 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Hs
		993417 CAP1_HUMAN (1-475): 0: 651: 62.71		ACTH_HUMAN (2-375): 0: 589: 93.58
+	Dm
		534492 Q9VPX7_DROME (45-474): 0: 552: 48.03		ACT1_DROME (2-375): 0: 598: 98.13
+	Dm
		534434 Q7KN55_DROME (4-474): 0: 551: 43.52		ACT1_DROME (2-375): 0: 598: 98.13
+	Dm
		387001 Q9VPX7_DROME (45-474): 0: 552: 48.03		ACT2_DROME (2-375): 0: 596: 97.59
+	Sp
		534528 CAP_SCHPO (14-473): 0: 532: 33.40		ACT_SCHPO (1-375): 0: 592: 90.40
+	Dm
		387000 Q9VPX6_DROME (4-474): 1e-180: 527: 43.73		ACT2_DROME (2-375): 0: 596: 97.59