HitPredict

Interactor 1: NRIP1 (P48552)
Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140)
Gene: NRIP1

Interactor 2: HDAC9 (Q9UKV0)
Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR)
Gene: HDAC9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	35914814
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000118 - histone deacetylase complex GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0042826 - histone deacetylase binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1158 Hs			1 1011
+	Hs
		819688 NRIP1_HUMAN (1-1158): 0: 2100: 100.00		HDAC5_HUMAN (1-1008): 0: 612: 55.67
+	Hs
		819626 NRIP1_HUMAN (1-1158): 0: 2100: 100.00		HDAC1_HUMAN (623-1009): 3.2e-140: 430: 23.49
+	Hs
		177230 NRIP1_HUMAN (1-1158): 0: 2100: 100.00		HDAC3_HUMAN (631-1007): 9.3e-131: 404: 22.34
+	Hs
		819658 NRIP1_HUMAN (1-1158): 0: 2100: 100.00		HDAC2_HUMAN (622-1009): 4.74e-130: 404: 22.67