HitPredict

Interactor 1: RAC1 (P40792)
Ras-related protein Rac1
Gene: RAC1

Interactor 2: SPRI (Q8MQW8)
Protein sprint (SH2 poly-proline-containing Ras-interactor protein)
Gene: SPRI

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	15710747
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RA~Ras, Ras~VPS9
Common GO terms	GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0048675 - axon extension GO:1903688 - positive regulation of border follicle cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Dm			1 1789
+	Dm
		874078 RAC2_DROME (1-192): 1.87e-80: 239: 93.23		SPRI_DROME (1-1789): 0: 1502: 100.00
+	Ce
		110101 RAC1_CAEEL (1-192): 1.77e-83: 246: 80.73		G5EBS9_CAEEL (1292-1786): 6.91e-134: 444: 27.30
+	Hs
		557206 RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67		SRC_HUMAN (330-574): 8.22e-56: 206: 16.86
+	Hs
		76673 B4E1U9_HUMAN (1-192): 1.14e-88: 261: 56.12		RIN3_HUMAN (458-969): 1.85e-49: 194: 20.19
+	Hs
		440481 RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67		FYN_HUMAN (318-575): 3.28e-55: 204: 17.42
+	Hs
		440334 RAC2_HUMAN (1-192): 3.07e-81: 241: 89.06		FYN_HUMAN (318-575): 3.28e-55: 204: 17.42
+	Hs
		440471 CDC42_HUMAN (1-192): 2.46e-78: 233: 69.27		FYN_HUMAN (318-575): 3.28e-55: 204: 17.42
+	Hs
		463050 RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67		YES_HUMAN (337-574): 2.32e-48: 184: 15.45
+	Hs
		462971 RAC2_HUMAN (1-192): 3.07e-81: 241: 89.06		YES_HUMAN (337-574): 2.32e-48: 184: 15.45
+	Hs
		463224 RHOJ_HUMAN (2-190): 4.29e-80: 239: 60.32		YES_HUMAN (337-574): 2.32e-48: 184: 15.45
+	Hs
		463041 CDC42_HUMAN (1-192): 2.46e-78: 233: 69.27		YES_HUMAN (337-574): 2.32e-48: 184: 15.45
+	Hs
		463059 RHOG_HUMAN (1-192): 3.53e-78: 233: 67.19		YES_HUMAN (337-574): 2.32e-48: 184: 15.45
+	Hs
		988441 RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67		TENS3_HUMAN (453-605): 1.03e-32: 141: 20.33
+	Hs
		581111 RAC2_HUMAN (1-192): 3.07e-81: 241: 89.06		TENS3_HUMAN (453-605): 1.03e-32: 141: 20.33
+	Hs
		319060 RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67		K0754_HUMAN (560-1141): 3.58e-25: 116: 15.63
+	Ce
		110770 RAC1_CAEEL (1-192): 1.77e-83: 246: 80.73		G5ECF0_CAEEL (333-646): 4.62e-24: 113: 22.74
+	Hs
		319049 RAC2_HUMAN (1-192): 3.07e-81: 241: 89.06		K0754_HUMAN (560-1141): 3.58e-25: 116: 15.63
+	Hs
		319077 RHOJ_HUMAN (2-190): 4.29e-80: 239: 60.32		K0754_HUMAN (560-1141): 3.58e-25: 116: 15.63
+	Hs
		319056 RAC3_HUMAN (1-191): 4.3e-78: 233: 89.53		K0754_HUMAN (560-1141): 3.58e-25: 116: 15.63
+	Hs
		319064 RHOG_HUMAN (1-192): 3.53e-78: 233: 67.19		K0754_HUMAN (560-1141): 3.58e-25: 116: 15.63