HitPredict

Interactor 1: UB2R1 (P49427)
Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1)
Gene: CDC34

Interactor 2: RNF31 (Q96EP0)
E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)
Gene: RNF31

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	30017913
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E3_UbLigase_RBR~UQ_con, IBR~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 236 Hs			1 1072
+	Hs
		1174522 UB2R2_HUMAN (1-203): 5.2e-79: 238: 84.73		RNF31_HUMAN (1-1072): 0: 1111: 100.00
+	Hs
		1290106 UB2D4_HUMAN (9-167): 3e-71: 216: 32.50		RNF31_HUMAN (1-1072): 0: 1111: 100.00
+	Hs
		849403 UB2D1_HUMAN (9-167): 2.94e-70: 213: 34.38		RNF31_HUMAN (1-1072): 0: 1111: 100.00
+	Hs
		919819 UB2D2_HUMAN (9-167): 3.51e-70: 213: 30.00		RNF31_HUMAN (1-1072): 0: 1111: 100.00
+	Mm
		895978 UB2D3_MOUSE (9-167): 3.52e-69: 210: 29.38		RNF31_MOUSE (1-1072): 0: 1083: 85.54
+	Hs
		849498 UB2D1_HUMAN (9-167): 2.94e-70: 213: 34.38		ARI1_HUMAN (600-1058): 1.52e-114: 367: 13.84
+	Hs
		312622 UB2R2_HUMAN (1-203): 5.2e-79: 238: 84.73		ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84
+	Hs
		312679 UB2D4_HUMAN (9-167): 3e-71: 216: 32.50		ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84
+	Hs
		312520 UB2D1_HUMAN (9-167): 2.94e-70: 213: 34.38		ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84
+	Hs
		312553 UB2D2_HUMAN (9-167): 3.51e-70: 213: 30.00		ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84
+	Dm
		639397 UBCD1_DROME (9-167): 1.26e-69: 211: 31.25		LUBEL_DROME (180-625): 2.05e-69: 257: 17.33
+	Hs
		1354303 UB2D4_HUMAN (9-167): 3e-71: 216: 32.50		RNF14_HUMAN (657-924): 3.51e-65: 230: 14.09
+	Hs
		849474 UB2D1_HUMAN (9-167): 2.94e-70: 213: 34.38		RNF14_HUMAN (657-924): 3.51e-65: 230: 14.09
+	Hs
		919891 UB2D2_HUMAN (9-167): 3.51e-70: 213: 30.00		RNF14_HUMAN (657-924): 3.51e-65: 230: 14.09
+	Hs
		842095 UB2D1_HUMAN (9-167): 2.94e-70: 213: 34.38		R144A_HUMAN (695-926): 5.41e-59: 206: 20.33
+	Hs
		842104 UB2D2_HUMAN (9-167): 3.51e-70: 213: 30.00		R144A_HUMAN (695-926): 5.41e-59: 206: 20.33
+	Hs
		919876 UB2D2_HUMAN (9-167): 3.51e-70: 213: 30.00		RN19A_HUMAN (698-946): 5.63e-54: 205: 21.21
+	Hs
		827867 UB2R1_HUMAN (1-236): 1.98e-95: 280: 100.00		RBP2_HUMAN (287-482): 4.73e-27: 122: 15.98
+	Hs
		919757 UB2D2_HUMAN (9-167): 3.51e-70: 213: 30.00		RN19B_HUMAN (698-946): 5.65e-42: 167: 22.43
+	Hs
		919893 UB2D2_HUMAN (9-167): 3.51e-70: 213: 30.00		ZRAN1_HUMAN (226-379): 5.88e-20: 97.7: 19.44