Protein: TENS3
Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6)

Gene: TENS3, TNS3
Organism: Homo sapiens
Interactions: 88
UniProt ID: Q68CZ2

Gene Ontology (top 5):
GO:0002102 - podosome
GO:0004721 - phosphoprotein phosphatase activity
GO:0005829 - cytosol
GO:0005925 - focal adhesion
GO:0035022 - positive regulation of Rac protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363413

EGFR
Epidermal growth factor receptor

5

20

Small-scale

0.937

High

834199

CSK
Tyrosine-protein kinase CSK

5

20

High-throughput

0.919

High

942680

BCAR1
Breast cancer anti-estrogen resistance protein 1

2

10

Small-scale

0.819

High

1051009

FAK1
Focal adhesion kinase 1

2

20

Small-scale

0.819

High

410898

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

557345

SRC
Proto-oncogene tyrosine-protein kinase Src

1

19

Small-scale

0.710

High

641612

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.696

High

1145742

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

932087

EPHA4
Ephrin type-A receptor 4

1

18

High-throughput

0.625

High

472078

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.619

High

532087

KIT
Mast/stem cell growth factor receptor Kit

1

13

High-throughput

0.619

High

269965

AUXI
Auxilin

1

13

High-throughput

0.618

High

400988

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.618

High

1104419

ILK
Scaffold protein ILK

1

7

Small-scale

0.618

High

1224824

TENS2
Tensin-2

1

14

High-throughput

0.618

High

1228511

PRAG1
Inactive tyrosine-protein kinase PRAG1

1

1

High-throughput

0.618

High

1228523

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

3

High-throughput

0.618

High

563905

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.585

High

1106482

GAB1
GRB2-associated-binding protein 1

1

6

High-throughput

0.536

High

387279

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.536

High

547457

DMD
Dystrophin

1

19

High-throughput

0.536

High

862662

UTRN
Utrophin

1

14

High-throughput

0.536

High

1104834

SNTB2
Beta-2-syntrophin

1

13

High-throughput

0.536

High

1118438

SNTB1
Beta-1-syntrophin

1

16

High-throughput

0.536

High

1228514

P5CR2
Pyrroline-5-carboxylate reductase 2

1

1

High-throughput

0.536

High

1228525

CTNL1
Alpha-catulin

1

2

High-throughput

0.536

High

1006474

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.501

High

262395

DTNB
Dystrobrevin beta

1

11

High-throughput

0.489

High

126649

RHOD
Rho-related GTP-binding protein RhoD

1

18

High-throughput

0.479

High

172936

XPO1
Exportin-1

1

8

High-throughput

0.479

High

325880

UBR5
E3 ubiquitin-protein ligase UBR5

1

15

High-throughput

0.479

High

345943

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

375613

RASK
GTPase KRas

1

8

High-throughput

0.479

High

532667

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

539068

UMPS
Uridine 5'-monophosphate synthase

1

2

High-throughput

0.479

High

581111

RAC2
Ras-related C3 botulinum toxin substrate 2

1

12

High-throughput

0.479

High

691117

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

729933

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

730665

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

731390

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

876013

TCPE
T-complex protein 1 subunit epsilon

1

5

High-throughput

0.479

High

878484

PAXI
Paxillin

1

9

High-throughput

0.479

High

891202

GSK3A
Glycogen synthase kinase-3 alpha

1

5

High-throughput

0.479

High

891618

GSK3B
Glycogen synthase kinase-3 beta

1

5

High-throughput

0.479

High

920035

PLK1
Serine/threonine-protein kinase PLK1

1

4

High-throughput

0.479

High

934736

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

966457

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

986492

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.479

High

988441

RAC1
Ras-related C3 botulinum toxin substrate 1

1

13

High-throughput

0.479

High

1045397

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

1049410

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1059871

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

1

Small-scale

0.479

High

1226856

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.479

High

1228507

RHOU
Rho-related GTP-binding protein RhoU

1

15

High-throughput

0.479

High

1228510

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

13

High-throughput

0.479

High

1228516

RHG07
Rho GTPase-activating protein 7

1

8

Small-scale

0.479

High

1228517

PASK
PAS domain-containing serine/threonine-protein kinase

1

2

High-throughput

0.479

High

1228518

TCPH
T-complex protein 1 subunit eta

1

5

High-throughput

0.479

High

1228519

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

5

High-throughput

0.479

High

1228522

RHOF
Rho-related GTP-binding protein RhoF

1

17

High-throughput

0.479

High

1228526

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1228529

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.479

High

335621

AGM1
Phosphoacetylglucosamine mutase

1

0

High-throughput

0.458

High

1228508

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.458

High

1228515

SPF45
Splicing factor 45

1

1

High-throughput

0.457

High

556150

CADH1
Cadherin-1

1

1

Small-scale

0.457

High

273881

CNOT3
CCR4-NOT transcription complex subunit 3

1

5

High-throughput

0.445

High

541030

PIM1
Serine/threonine-protein kinase pim-1

1

3

High-throughput

0.445

High

930933

HSP72
Heat shock-related 70 kDa protein 2

1

5

High-throughput

0.445

High

1228520

CARD9
Caspase recruitment domain-containing protein 9

1

5

High-throughput

0.445

High

1228521

ELL3
RNA polymerase II elongation factor ELL3

1

2

High-throughput

0.445

High

1228528

FBW1B
F-box/WD repeat-containing protein 11

1

12

High-throughput

0.445

High

372279

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.437

High

377602

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

2

High-throughput

0.437

High

601329

RHOQ
Rho-related GTP-binding protein RhoQ

1

14

High-throughput

0.437

High

606851

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.437

High

693331

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

4

High-throughput

0.437

High

1114889

CUL4A
Cullin-4A

1

10

High-throughput

0.437

High

1228509

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.437

High

1228513

ESR2
Estrogen receptor beta

1

15

High-throughput

0.437

High

1228527

XPO7
Exportin-7

1

6

High-throughput

0.437

High

1228530

HECD1
E3 ubiquitin-protein ligase HECTD1

1

12

High-throughput

0.437

High

330197

VENTX
Homeobox protein VENTX

1

3

High-throughput

0.407

High

1228524

WRP73
WD repeat-containing protein WRAP73

1

4

High-throughput

0.407

High

1228531

GPSM3
G-protein-signaling modulator 3

1

1

High-throughput

0.407

High

379259

IGHG1
Immunoglobulin heavy constant gamma 1

1

0

High-throughput

0.232

Low

1064996

FGL1
Fibrinogen-like protein 1

1

0

High-throughput

0.232

Low

1228512

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025