HitPredict

Interactor 1: UB2R1 (P49427)
Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1)
Gene: CDC34

Interactor 2: RBX2 (Q9UBF6)
RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein)
Gene: RNF7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	20638939, 31253590, 16874460
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-rbx1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 236 Hs			1 113
+	Hs
		827903 UB2R1_HUMAN (1-236): 1.98e-95: 280: 100.00		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Hs
		921315 UB2R2_HUMAN (1-203): 5.2e-79: 238: 84.73		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Mm
		921502 UB2R2_MOUSE (1-203): 5.2e-79: 238: 84.73		RBX1_MOUSE (18-112): 5.7e-38: 125: 46.94
+	Hs
		921482 UB2D4_HUMAN (9-167): 3e-71: 216: 32.50		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Hs
		828023 UB2R1_HUMAN (1-236): 1.98e-95: 280: 100.00		RN167_HUMAN (48-105): 7.89e-11: 59: 25.42
+	Sc
		539491 UBC3_YEAST (7-232): 1.2e-70: 219: 34.35		RBX1_YEAST (6-113): 1.27e-35: 119: 41.44
+	Ce
		715111 UBC2_CAEEL (9-167): 1.33e-70: 214: 31.25		RBX1_CAEEL (9-112): 1.41e-37: 124: 39.25
+	Mm
		895979 UB2D1_MOUSE (9-167): 2.94e-70: 213: 34.38		RBX1_MOUSE (18-112): 5.7e-38: 125: 46.94
+	Hs
		919703 UB2D2_HUMAN (9-167): 3.51e-70: 213: 30.00		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Mm
		919923 UB2D2_MOUSE (9-167): 3.51e-70: 213: 30.00		RBX1_MOUSE (18-112): 5.7e-38: 125: 46.94
+	Hs
		1174502 UB2R2_HUMAN (1-203): 5.2e-79: 238: 84.73		DZIP3_HUMAN (4-103): 1.17e-23: 96: 20.76
+	Hs
		1354003 UB2D4_HUMAN (9-167): 3e-71: 216: 32.50		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		1205159 UB2D4_HUMAN (9-167): 3e-71: 216: 32.50		DZIP3_HUMAN (4-103): 1.17e-23: 96: 20.76
+	Hs
		919775 UB2D2_HUMAN (9-167): 3.51e-70: 213: 30.00		DZIP3_HUMAN (4-103): 1.17e-23: 96: 20.76
+	Ce
		715108 UBC2_CAEEL (9-167): 1.33e-70: 214: 31.25		APC11_CAEEL (2-110): 4.96e-25: 93.3: 28.57
+	Hs
		207572 UB2D4_HUMAN (9-167): 3e-71: 216: 32.50		RNF13_HUMAN (29-110): 1.3e-17: 78.3: 26.51
+	Hs
		207553 UB2D2_HUMAN (9-167): 3.51e-70: 213: 30.00		RNF13_HUMAN (29-110): 1.3e-17: 78.3: 26.51
+	Hs
		919766 UB2D2_HUMAN (9-167): 3.51e-70: 213: 30.00		SYVN1_HUMAN (54-105): 4.48e-17: 77.1: 26.92
+	Hs
		1332598 UB2D4_HUMAN (9-167): 3e-71: 216: 32.50		RN167_HUMAN (48-105): 7.89e-11: 59: 25.42
+	Hs
		1346940 UB2D4_HUMAN (9-167): 3e-71: 216: 32.50		RNF12_HUMAN (49-104): 2.17e-10: 57.9: 23.21