HitPredict

Interactor 1: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Interactor 2: ERCC6 (Q03468)
DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)
Gene: ERCC6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 140 Hs			1 1493
+	Hs
		934683 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		ERCC6_HUMAN (1-1493): 0: 1168: 100.00
+	Hs
		828310 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		CHD6_HUMAN (107-1487): 0: 818: 17.66
+	Hs
		935014 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD6_HUMAN (107-1487): 0: 818: 17.66
+	Hs
		935016 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD5_HUMAN (300-1446): 0: 783: 19.15
+	Hs
		828410 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		CHD7_HUMAN (3-1479): 0: 774: 17.81
+	Hs
		935324 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD7_HUMAN (3-1479): 0: 774: 17.81
+	Hs
		828213 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		CHD3_HUMAN (303-1446): 0: 759: 19.68
+	Hs
		934770 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD4_HUMAN (303-1439): 0: 766: 18.35
+	Hs
		1059677 H3C_HUMAN (5-134): 5.15e-52: 162: 47.69		CHD4_HUMAN (303-1439): 0: 766: 18.35
+	Hs
		934705 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD3_HUMAN (303-1446): 0: 759: 19.68
+	Hs
		935262 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CHD8_HUMAN (2-1474): 0: 725: 16.46
+	Hs
		658641 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		SMCA1_HUMAN (369-1372): 0: 700: 20.58
+	Hs
		229341 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		SMCA5_HUMAN (368-1383): 0: 698: 20.75
+	Mm
		935460 H31_MOUSE (5-134): 1.29e-52: 164: 48.86		SMCA5_MOUSE (366-1383): 0: 703: 21.00
+	Hs
		658647 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SMCA1_HUMAN (369-1372): 0: 700: 20.58
+	Hs
		229359 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SMCA5_HUMAN (368-1383): 0: 698: 20.75
+	Hs
		846921 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SMCA4_HUMAN (228-1324): 0: 677: 19.90
+	Hs
		828175 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		SMCA2_HUMAN (228-1247): 0: 660: 19.72
+	Hs
		846743 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SMCA2_HUMAN (228-1247): 0: 660: 19.72
+	Hs
		935434 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		RA54B_HUMAN (502-1007): 8.21e-77: 276: 34.33