HitPredict

Interactor 1: CEBPA (P49715)
CCAAT/enhancer-binding protein alpha (C/EBP alpha)
Gene: CEBPA

Interactor 2: TRIB1 (Q96RU8)
Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1)
Gene: TRIB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	30254053, 26455797
Identification Methods	pull down, unspecified method, isothermal titration calorimetry
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 358 Hs			1 372
+	Mm
		862857 CEBPA_MOUSE (1-358): 4.3e-64: 209: 91.19		TRIB1_MOUSE (1-372): 8.58e-128: 373: 93.82
+	Hs
		831529 CEBPA_HUMAN (1-358): 1.35e-69: 223: 100.00		TRIB2_HUMAN (52-371): 1.1e-115: 341: 60.25
+	Mm
		862856 CEBPA_MOUSE (1-358): 4.3e-64: 209: 91.19		TRIB2_MOUSE (52-371): 6.83e-114: 336: 59.63
+	Hs
		569980 CEBPB_HUMAN (51-357): 3.68e-47: 164: 31.61		TRIB1_HUMAN (1-372): 7.49e-123: 360: 100.00
+	Hs
		547787 ATF2_HUMAN (46-352): 2.46e-30: 122: 10.97		KPCE_HUMAN (11-371): 2.39e-128: 387: 17.32
+	Mm
		656011 CEBPB_MOUSE (55-357): 1.43e-33: 127: 30.36		TRIB1_MOUSE (1-372): 8.58e-128: 373: 93.82
+	Hs
		1077833 CEBPE_HUMAN (36-358): 7.89e-34: 128: 36.92		TRIB1_HUMAN (1-372): 7.49e-123: 360: 100.00
+	Hs
		831923 CEBPD_HUMAN (89-355): 4.07e-31: 120: 28.84		TRIB1_HUMAN (1-372): 7.49e-123: 360: 100.00
+	Dm
		971936 CEBP_DROME (145-345): 1.87e-20: 94: 23.01		TRIB_DROME (107-338): 2.97e-52: 182: 41.54