HitPredict

Interactor 1: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Interactor 2: WDR6 (Q9NNW5)
tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6)
Gene: WDR6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 499 Hs			1 1121
+	Hs
		1342219 DYR1B_HUMAN (108-488): 2.22e-110: 342: 29.03		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		1044171 DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		625337 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21
+	Hs
		929595 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21
+	Hs
		254043 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		WDR1_HUMAN (538-1119): 1.07e-31: 134: 9.41
+	Hs
		833786 CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31		GEMI5_HUMAN (758-1120): 9.39e-16: 85.1: 9.37
+	Sp
		999840 LKH1_SCHPO (25-481): 2.39e-116: 359: 33.05		TUP11_SCHPO (759-1119): 9.81e-29: 125: 16.94
+	Hs
		415113 CDK1_HUMAN (160-485): 3.05e-114: 340: 23.95		FBW1A_HUMAN (30-284): 7.71e-34: 140: 13.41
+	Hs
		1044288 DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50		FBW1A_HUMAN (30-284): 7.71e-34: 140: 13.41
+	Hs
		625543 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75
+	Sp
		1013593 LKH1_SCHPO (25-481): 2.39e-116: 359: 33.05		TUP12_SCHPO (126-327): 1.91e-15: 82.9: 17.96
+	Hs
		1074800 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		TAF5_HUMAN (191-376): 1.08e-13: 77.9: 23.71
+	Hs
		1268574 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75
+	At
		188998 AFC2_ARATH (136-483): 6.83e-118: 355: 47.35		GBLPA_ARATH (88-239): 1.98e-11: 68.8: 9.43
+	Ce
		1000139 MBK2_CAEEL (145-487): 5.44e-111: 349: 27.93		LIN23_CAEEL (30-203): 5.5e-11: 68.8: 12.22
+	Hs
		415016 CDK1_HUMAN (160-485): 3.05e-114: 340: 23.95		FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75
+	Hs
		903402 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		WDR5_HUMAN (390-646): 7.51e-09: 60.7: 13.53
+	At
		1106372 MPK4_ARATH (166-497): 5.02e-112: 338: 21.89		LST81_ARATH (137-308): 8.15e-13: 72.5: 22.16
+	Hs
		1044022 DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50		FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75
+	Dm
		1363665 Q9W0Q1_DROME (131-478): 5.28e-42: 162: 29.47		Q9VDE3_DROME (132-344): 9.8e-13: 74.1: 16.82