HitPredict

Interactor 1: CLK3 (P49761)
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
Gene: CLK3

Interactor 2: SIR1 (Q96EB6)
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: SIRT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 638 Hs			1 747
+	Hs
		625550 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		SIR1_HUMAN (1-747): 0: 1052: 100.00
+	Hs
		1044039 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		SIR1_HUMAN (1-747): 0: 1052: 100.00
+	Hs
		213903 DYRK3_HUMAN (95-628): 2.8e-118: 366: 22.89		SIR1_HUMAN (1-747): 0: 1052: 100.00
+	Hs
		415021 CDK1_HUMAN (301-624): 5.68e-119: 357: 24.70		SIR1_HUMAN (1-747): 0: 1052: 100.00
+	Mm
		1142386 DYR1A_MOUSE (181-637): 2.9e-122: 382: 26.45		SIR1_MOUSE (1-747): 0: 957: 84.89
+	Mm
		1265756 DYRK3_MOUSE (95-634): 5.41e-118: 365: 23.04		SIR1_MOUSE (1-747): 0: 957: 84.89
+	Mm
		509491 CDK1_MOUSE (301-624): 1.05e-117: 354: 24.10		SIR1_MOUSE (1-747): 0: 957: 84.89
+	Hs
		625510 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		SIR2_HUMAN (210-559): 8.78e-120: 366: 34.13
+	Hs
		1043955 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		SIR6_HUMAN (230-546): 7.12e-92: 292: 21.77
+	Hs
		414992 CDK1_HUMAN (301-624): 5.68e-119: 357: 24.70		SIR6_HUMAN (230-546): 7.12e-92: 292: 21.77
+	Hs
		415079 CDK1_HUMAN (301-624): 5.68e-119: 357: 24.70		SIR7_HUMAN (179-541): 2.86e-87: 282: 19.15