Protein: MED16
Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) (Thyroid hormone receptor-associated protein 5) (Thyroid hormone receptor-associated protein complex 95 kDa component) (Trap95) (Vitamin D3 receptor-interacting protein complex 92 kDa component) (DRIP92)

Gene: MED16
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q9Y2X0

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0006366 - transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1451899

MED29
Mediator of RNA polymerase II transcription subunit 29

4

1

High-throughput

0.903

High

1461616

MED23
Mediator of RNA polymerase II transcription subunit 23

4

1

Small-scale

0.900

High

1259296

MED25
Mediator of RNA polymerase II transcription subunit 25

4

1

Small-scale

0.881

High

282432

MED24
Mediator of RNA polymerase II transcription subunit 24

3

1

Small-scale

0.847

High

1401578

MED15
Mediator of RNA polymerase II transcription subunit 15

3

1

Small-scale

0.827

High

881630

CDK8
Cyclin-dependent kinase 8

13

3

Small-scale

0.761

High

1151314

MED1
Mediator of RNA polymerase II transcription subunit 1

7

1

Small-scale

0.746

High

1413644

MED10
Mediator of RNA polymerase II transcription subunit 10

7

1

Small-scale

0.745

High

1369184

KAT2A
Histone acetyltransferase KAT2A

2

2

Small-scale

0.737

High

1416412

CDK19
Cyclin-dependent kinase 19

6

3

High-throughput

0.733

High

49042

MED19
Mediator of RNA polymerase II transcription subunit 19

8

0

Small-scale

0.720

High

1414154

MED18
Mediator of RNA polymerase II transcription subunit 18

5

1

High-throughput

0.718

High

1446562

MED4
Mediator of RNA polymerase II transcription subunit 4

5

1

High-throughput

0.716

High

1380274

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.716

High

666935

CCNC
Cyclin-C

5

1

High-throughput

0.706

High

219528

MED7
Mediator of RNA polymerase II transcription subunit 7

4

1

High-throughput

0.699

High

1436793

MED20
Mediator of RNA polymerase II transcription subunit 20

4

1

High-throughput

0.699

High

1372219

MED12
Mediator of RNA polymerase II transcription subunit 12

4

2

High-throughput

0.694

High

1450396

MED17
Mediator of RNA polymerase II transcription subunit 17

4

1

High-throughput

0.691

High

1108419

MED21
Mediator of RNA polymerase II transcription subunit 21

5

0

High-throughput

0.690

High

1431408

MED28
Mediator of RNA polymerase II transcription subunit 28

5

0

High-throughput

0.684

High

1451145

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.661

High

397276

ESR1
Estrogen receptor

3

5

Small-scale

0.660

High

239635

MED14
Mediator of RNA polymerase II transcription subunit 14

3

1

Small-scale

0.656

High

1367646

ESR2
Estrogen receptor beta

3

5

Small-scale

0.641

High

260636

BRD4
Bromodomain-containing protein 4

3

1

Small-scale

0.640

High

336043

MED26
Mediator of RNA polymerase II transcription subunit 26

3

0

High-throughput

0.638

High

1149722

MED22
Mediator of RNA polymerase II transcription subunit 22

3

0

High-throughput

0.638

High

1405919

DNJC7
DnaJ homolog subfamily C member 7

3

0

High-throughput

0.634

High

1490976

MED31
Mediator of RNA polymerase II transcription subunit 31

2

1

High-throughput

0.628

High

287831

MED6
Mediator of RNA polymerase II transcription subunit 6

2

1

High-throughput

0.611

High

1241424

MED27
Mediator of RNA polymerase II transcription subunit 27

2

1

High-throughput

0.611

High

1391346

MED8
Mediator of RNA polymerase II transcription subunit 8

2

1

High-throughput

0.611

High

1453733

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.611

High

1460086

MED13
Mediator of RNA polymerase II transcription subunit 13

2

2

High-throughput

0.601

High

319188

ST65G
STAGA complex 65 subunit gamma

1

0

Small-scale

0.586

High

869100

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.586

High

998980

H31
Histone H3.1

1

0

Small-scale

0.586

High

1212058

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.586

High

543553

VDR
Vitamin D3 receptor

2

2

Small-scale

0.584

High

1393389

MED30
Mediator of RNA polymerase II transcription subunit 30

2

1

Small-scale

0.584

High

533311

THA
Thyroid hormone receptor alpha

2

4

Small-scale

0.571

High

1227745

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.553

High

1048403

ACVR1
Activin receptor type-1

2

0

High-throughput

0.547

High

638559

FPR1
fMet-Leu-Phe receptor

1

0

High-throughput

0.546

High

1490977

TRRAP
Transformation/transcription domain-associated protein

1

0

Small-scale

0.546

High

1152999

CEBPE
CCAAT/enhancer-binding protein epsilon

1

1

High-throughput

0.541

High

1434286

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.517

High

123883

MYO1C
Unconventional myosin-Ic

1

0

High-throughput

0.513

High

170444

AURKA
Aurora kinase A

1

0

High-throughput

0.513

High

220044

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

486643

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

584166

FOSL2
Fos-related antigen 2

1

0

High-throughput

0.513

High

723147

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.513

High

976179

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.513

High

1243790

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

834098

HNF4A
Hepatocyte nuclear factor 4-alpha

1

6

Small-scale

0.501

High

590510

GATA1
Erythroid transcription factor

1

2

Small-scale

0.500

High

373557

MYC
Myc proto-oncogene protein

1

0

Small-scale

0.480

High

1490978

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

Small-scale

0.480

High

143344

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

283577

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

414891

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

474392

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.479

High

520473

ANDR
Androgen receptor

1

5

High-throughput

0.479

High

905316

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

1014670

SMAD3
Mothers against decapentaplegic homolog 3

1

2

Small-scale

0.479

High

1088114

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

1133749

NFIX
Nuclear factor 1 X-type

1

3

High-throughput

0.479

High

1153952

SMAD2
Mothers against decapentaplegic homolog 2

1

2

Small-scale

0.479

High

1154032

SMAD1
Mothers against decapentaplegic homolog 1

1

2

Small-scale

0.479

High

1259082

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

2

High-throughput

0.479

High

1295684

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

1

2

High-throughput

0.479

High

171791

GAK
Cyclin-G-associated kinase

1

0

High-throughput

0.458

High

283634

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.458

High

320804

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

696921

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

1005266

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1029979

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

1120405

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

Small-scale

0.458

High

1257848

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1329960

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1368419

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.458

High

1400102

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

1407438

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

1434848

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

1458434

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.458

High

1460321

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1462605

SATB2
DNA-binding protein SATB2

1

0

Small-scale

0.458

High

95766

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

1461716

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

253998

LPXN
Leupaxin

1

0

High-throughput

0.426

High

401734

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.426

High

1401910

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1404529

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.426

High

887360

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

76446

B4DUB1
cyclin-dependent kinase

1

3

High-throughput

0.407

High

914508

EFNB2
Ephrin-B2

2

0

High-throughput

0.298

High

1328777

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

0

High-throughput

0.282

High

295659

CIB2
Calcium and integrin-binding family member 2

1

0

High-throughput

0.279

Low

347430

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

1136418

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.279

Low

1399649

OPALI
Opalin

1

0

High-throughput

0.279

Low

1403477

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

352654

TCL1B
T-cell leukemia/lymphoma protein 1B

1

0

High-throughput

0.249

Low

412853

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1214835

ATD3B
ATPase family AAA domain-containing protein 3B

1

0

High-throughput

0.249

Low

1454781

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025