Protein: MED16
Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16)

Gene: MED16
Organism: Drosophila melanogaster
Interactions: 55
UniProt ID: Q9W278

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0009408 - response to heat
GO:0016592 - mediator complex
GO:0032496 - response to lipopolysaccharide

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1267080

MED29
Mediator of RNA polymerase II transcription subunit 29

2

1

High-throughput

0.737

High

1377817

EBI
F-box-like/WD repeat-containing protein ebi

2

1

High-throughput

0.737

High

1489651

MED23
Mediator of RNA polymerase II transcription subunit 23

2

1

High-throughput

0.737

High

1489731

MED15
Mediator of RNA polymerase II transcription subunit 15

1

1

High-throughput

0.618

High

1471850

MED25
Mediator of RNA polymerase II transcription subunit 25

1

1

High-throughput

0.575

High

1485581

MED24
Mediator of RNA polymerase II transcription subunit 24

1

1

High-throughput

0.575

High

58522

MED8
Mediator of RNA polymerase II transcription subunit 8

2

1

High-throughput

0.571

High

1019310

MED20
Mediator of RNA polymerase II transcription subunit 20

2

1

High-throughput

0.571

High

1269648

MED13
Mediator of RNA polymerase II transcription subunit 13

2

2

High-throughput

0.571

High

1321592

MED6
Mediator of RNA polymerase II transcription subunit 6

2

1

High-throughput

0.571

High

1428011

MED10
Mediator of RNA polymerase II transcription subunit 10

2

1

High-throughput

0.571

High

1428119

MED7
Mediator of RNA polymerase II transcription subunit 7

2

1

High-throughput

0.571

High

1472624

MED17
Mediator of RNA polymerase II transcription subunit 17

2

1

High-throughput

0.571

High

1473457

Q9VF03
Brahma associated protein 155 kDa

2

2

High-throughput

0.571

High

1485352

MED4
Mediator of RNA polymerase II transcription subunit 4

2

1

High-throughput

0.571

High

1485969

CDK8
Cyclin-dependent kinase 8

2

3

High-throughput

0.571

High

1487443

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.571

High

1489433

MED30
Mediator of RNA polymerase II transcription subunit 30

2

1

High-throughput

0.571

High

1489442

MED14
Mediator of RNA polymerase II transcription subunit 14

2

1

High-throughput

0.571

High

1489730

MED18
Mediator of RNA polymerase II transcription subunit 18

2

1

High-throughput

0.571

High

1261444

Q7JQT8
LD41464p

2

0

High-throughput

0.547

High

1488715

BAP60
Brahma-associated protein of 60 kDa

2

0

High-throughput

0.547

High

53615

A1Z813
Secretory 24AB, isoform A

2

1

High-throughput

0.521

High

628550

USP
Protein ultraspiracle

1

5

Small-scale

0.479

High

1302906

MED31
Mediator of RNA polymerase II transcription subunit 31

1

1

High-throughput

0.445

High

1305684

Q8IQX7
Beadex, isoform B

1

1

High-throughput

0.445

High

1482750

MED27
Mediator of RNA polymerase II transcription subunit 27

1

1

High-throughput

0.445

High

1483021

MED1
Mediator of RNA polymerase II transcription subunit 1

1

1

High-throughput

0.445

High

1487592

MED12
Mediator of RNA polymerase II transcription subunit 12

1

2

High-throughput

0.445

High

197498

O18353
CHIP

1

0

High-throughput

0.426

High

1171943

Q24090
GH08712p

1

0

High-throughput

0.426

High

1303641

OSA
Trithorax group protein osa

1

0

High-throughput

0.426

High

1306464

INDRA
Zinc finger protein indra

1

0

High-throughput

0.426

High

1409410

Q9BIW6
Brahma-associated protein 111kD

1

0

High-throughput

0.426

High

1489729

Q9W3G1
Uncharacterized protein, isoform A

1

0

High-throughput

0.426

High

1343934

Q8SXP8
TAR DNA-binding protein 43

1

3

High-throughput

0.407

High

1472596

Q9VEB9
Sequence-specific single-stranded DNA-binding protein, isoform A

1

4

High-throughput

0.407

High

1482725

Q9VNF8
Protein transport protein SEC23

1

1

High-throughput

0.407

High

900691

DSH
Segment polarity protein dishevelled

2

0

High-throughput

0.298

High

1346463

MESD
LDLR chaperone boca

2

0

High-throughput

0.298

High

1378960

Q960F7
SD03629p

2

0

High-throughput

0.298

High

1480280

Q9VL29
GEO11246p1

2

0

High-throughput

0.298

High

1485619

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

0

High-throughput

0.298

High

1486611

Q9VUB7
PAX-interacting protein 1

2

0

High-throughput

0.298

High

1489385

Q9W0L7
ubiquitinyl hydrolase 1

2

0

High-throughput

0.298

High

1484630

Q9VR42
Serine/threonine-protein kinase RIO3

1

0

High-throughput

0.249

Low

1488891

Q9VYZ8
GEO08286p1

1

0

High-throughput

0.249

Low

56965

A1ZAK7
LD35640p

1

0

High-throughput

0.232

Low

638681

MAM
Neurogenic protein mastermind

1

0

High-throughput

0.232

Low

1069947

Q0E996
Eukaryotic translation initiation factor 4 gamma 2

1

0

High-throughput

0.232

Low

1175509

NETB
Netrin-B

1

0

High-throughput

0.232

Low

1321536

ENC
Protein encore

1

0

High-throughput

0.232

Low

1345941

Q8T4A8
AT07769p

1

0

High-throughput

0.232

Low

1440716

LAR4
La-related protein Larp4B

1

0

High-throughput

0.232

Low

1489519

Q9W124
LD27920p

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025