HitPredict

Interactor 1: SYIC (P41252)
Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)
Gene: IARS1

Interactor 2: SYLC (Q9P2J5)
Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS)
Gene: LARS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.960

The method score is based on:

Property Details
Experiments 33961781, 36347866, 35235311, 28524877, 28514442, 27684187, 31839598
Identification Methods affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Anticodon_1~Anticodon_1, Anticodon_1~tRNA-synt_1, Anticodon_1~DUF5915, tRNA-synt_1~tRNA-synt_1
Common GO terms GO:0002161 - aminoacyl-tRNA deacylase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006418 - tRNA aminoacylation for protein translation
and 1 others

more...
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 1262
Hs

1 1176
+ Hs
+ Zm
+ Sc
+ Ec
+ Mm

Service provided by Combinatics, Japan

Last updated: 11Aug2025