HitPredict

Interactor 1: TSC2 (P49815)
Tuberin (Tuberous sclerosis 2 protein)
Gene: TSC2

Interactor 2: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.728

Property	Details
Experiments	35271311, 36931259, 17979178, 19608861, 16636147, 12438239
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1807 Hs			1 255
+	Hs
		909678 RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		196427 SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Dm
		114606 M9PD17_DROME (1255-1756): 5.21e-86: 315: 31.22		1433E_DROME (1-254): 2.95e-146: 411: 82.69
+	Dm
		955043 Q9VW83_DROME (1255-1756): 5.71e-86: 315: 31.22		1433E_DROME (1-254): 2.95e-146: 411: 82.69
+	Hs
		910116 SI1L2_HUMAN (1459-1800): 2.08e-79: 293: 20.17		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		230231 SI1L3_HUMAN (1459-1807): 3.43e-77: 286: 21.33		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		812874 RPGP1_HUMAN (1513-1765): 1.64e-69: 250: 24.23		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909669 RPGP2_HUMAN (1471-1758): 2.83e-66: 242: 22.03		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00