Protein: EFS
Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)

Gene: EFS
Organism: Homo sapiens
Interactions: 42
UniProt ID: O43281

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005925 - focal adhesion
GO:0007155 - cell adhesion
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
GO:0016477 - cell migration

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211971

FYN
Tyrosine-protein kinase Fyn

5

20

Small-scale

0.931

High

211982

BLK
Tyrosine-protein kinase Blk

5

20

High-throughput

0.930

High

211967

SRBS2
Sorbin and SH3 domain-containing protein 2

3

20

High-throughput

0.871

High

211995

OSTF1
Osteoclast-stimulating factor 1

2

20

High-throughput

0.817

High

211974

SRC
Proto-oncogene tyrosine-protein kinase Src

2

20

Small-scale

0.785

High

211972

YES
Tyrosine-protein kinase Yes

2

20

High-throughput

0.783

High

211994

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

2

19

High-throughput

0.783

High

211981

CRK
Adapter molecule crk

2

20

Small-scale

0.768

High

211963

NCK2
Cytoplasmic protein NCK2

2

20

High-throughput

0.743

High

212000

ABI2
Abl interactor 2

5

19

High-throughput

0.722

High

211990

SH2D3
SH2 domain-containing protein 3C

2

20

High-throughput

0.702

High

211993

SH3R2
E3 ubiquitin-protein ligase SH3RF2

2

20

High-throughput

0.700

High

211964

VINEX
Vinexin

1

20

High-throughput

0.698

High

211983

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

15

High-throughput

0.698

High

211973

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

High-throughput

0.647

High

211966

TPC6A
Trafficking protein particle complex subunit 6A

3

0

High-throughput

0.639

High

211969

ABL1
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.618

High

211999

TSSK1
Testis-specific serine/threonine-protein kinase 1

3

3

High-throughput

0.616

High

211986

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

1

High-throughput

0.606

High

211975

NCK1
SH2/SH3 adapter protein NCK1

2

20

High-throughput

0.586

High

211996

GLMN
Glomulin

2

0

High-throughput

0.580

High

211968

GPAN1
G patch domain and ankyrin repeat-containing protein 1

2

9

High-throughput

0.553

High

211978

AGT1
Alanine--glyoxylate aminotransferase

2

1

High-throughput

0.553

High

211987

LHX8
LIM/homeobox protein Lhx8

2

11

High-throughput

0.553

High

211977

NF1
Neurofibromin

1

7

High-throughput

0.541

High

211980

BKRB2
B2 bradykinin receptor

1

1

High-throughput

0.541

High

211965

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.523

High

211970

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

211985

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

12

Small-scale

0.501

High

211998

NPAS2
Neuronal PAS domain-containing protein 2

1

2

High-throughput

0.494

High

211997

LYST
Lysosomal-trafficking regulator

1

5

Small-scale

0.481

High

211979

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

12

High-throughput

0.479

High

211984

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.479

High

211988

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

212001

NLGN3
Neuroligin-3

1

2

Small-scale

0.464

High

211976

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

0

High-throughput

0.458

High

3270

A0A0S2Z4D7
NCK adaptor protein 1 isoform 2

1

20

High-throughput

0.417

High

3283

A0A0S2Z4E4
NCK adaptor protein 1 isoform 3

1

20

High-throughput

0.417

High

95922

E7ERP6
NCK adaptor protein 2

1

20

High-throughput

0.417

High

211989

Q8IVT4
Hypothetical MGC50722

2

0

High-throughput

0.316

High

211992

MYOZ3
Myozenin-3

2

0

High-throughput

0.316

High

211991

ZN417
Zinc finger protein 417

1

0

High-throughput

0.299

High


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Last updated: 11Aug2025